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Effects of a Single Course of Deferoxamine in Neuroblastoma Patients¹

Pediatric Oncology Service, Ospedale Bambino Gesu' [A. D., G. D., D. P.] and Department of Pediatrics, University "La Sapienza" [C. D., M. A. C.], Rome, Italy, and Department of Pediatrics, New York Medical College, New York, New York [L. H.]

A phase II trial of a single 5-day course of deferoxamine in 9 patients with neuroblastomas was completed. Within 2 days of completion of treatment responses were observed in 7 of 9 patients and there was no drug toxicity. These responses were a decrease in bone marrow infiltration and, in one patient, a measurable reduction in her tumor mass. We conclude that deferoxamine given as an 8-h i.v. infusion daily for 5 days at 150 mg/kg/day has antitumor activity.

¹ This work was supported by the Neuroblastoma Foundation of New York.

² To whom requests for reprints should be addressed, at Servizio di Oncologia, Ospedale Bambino Gesu', Piazza S. Onofrio, 4, 00165 Rome, Italy.

Received 9/11/89. Revised 4/16/90.

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