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Synergistic Interactions between Cyclophosphamide or Melphalan and VP-16 in a Human Rhabdomyosarcoma Xenograft¹

Departments of Pediatrics [E. R. L., M. C. R., H. S. F.], Pathology [D. D. B., H. S. F.] and Medicine [G. B. E.], and the Preuss Laboratory for Brain Tumor Research [D. D. B.], Duke University Medical Center, Durham, NC 27710; and the Johns Hopkins Oncology Center, Baltimore, MD 21205 [O. M. C.]

Based on previous work demonstrating the activity of cyclophosphamide and melphalan in a series of human medulloblastoma and rhabdomyosarcoma cell lines and transplantable xenografts, investigations were conducted to define the effects of combining cyclophosphamide or melphalan with VP-16. These studies demonstrated a synergistic interaction between cyclophosphamide and VP-16 and melphalan and VP-16 in the treatment of the human rhabdomyosarcoma cell line TE-671 growing in athymic mice. The combination of cyclophosphamide or melphalan with VP-16 may warrant consideration as a therapeutic strategy for solid tumors sensitive to bifunctional alkylating agents.

¹ Supported by NIH Grants CA 11898, CA 44640, NS 20023, and NS 00958, ACS Grant CH-403, and Bristol-Myers Research Grant R-18.

² To whom requests for reprints should be addressed, at P. O. Box 2916, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710.

Received 10/19/88. Revised 10/ 4/89. Accepted 10/16/89.

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