This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Triozzi, P. L. Articles by Grever, M. R. Search for Related Content PubMed PubMed Citation Articles by Triozzi, P. L. Articles by Grever, M. R.

Immunological Effects of Flavone Acetic Acid

Division of Hematology-Oncology, Department of Medicine, The Ohio State University [P. L. T., J. J. R., M. R. G.], and The Ohio State University Comprehensive Cancer Center [D. C. Y., L. M.], Columbus, Ohio 43210

Flavone acetic acid (FAA) enhances natural killer and lymphokineactivated killer (LAK) cell activity in mice. We examined the immunological effects of FAA on human blood cells both in vivo and in vitro. Peripheral blood natural killer and LAK activity and lymphocyte subsets were evaluated in cancer patients after receiving 3-h infusion of FAA at either 8.5 or 10 g/m² with alkalinization. Natural killer cell activity and the number of Leu-19 (CD56) positive cells decreased at 24 h after infusion; significant changes in LAK activity and the number of Leu-1 (CD5), Leu-3 (CD4), Leu-2 (CD8) cells were not observed. Peripheral blood mononuclear cells and peripheral blood lymphocytes collected from healthy volunteers were exposed in vitro to FAA, interleukin 2, and FAA plus interleukin 2. FAA, alone or in combination, failed to enhance LAK activity at any time point or concentration from peripheral blood mononuclear cells and peripheral blood lymphocytes. Concentrations of 100 µg/ml antagonized the generation of LAK activity from interleukin 2 treated peripheral blood lymphocytes. These data suggest that FAA may not be useful in enhancing immunological responses in humans.

Received 2/19/90. Accepted 7/17/90.