This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Longnecker, D. S. Articles by Freeman, D. H. Search for Related Content PubMed PubMed Citation Articles by Longnecker, D. S. Articles by Freeman, D. H., Jr.

Characterization of the Elastase 1-Simian Virus 40 T-Antigen Mouse Model of Pancreatic Carcinoma: Effects of Sex and Diet¹

Department of Pathology [D. S. L., E. T. K.], and Department of Community and Family Medicine [D. H. F.], Dartmouth Medical School, Hanover, New Hampshire 03756

Elastase 1-simian virus transgenic mice, strain Tg(Ela-1, SV40E) Bri18, were studied to characterize the development of pancreatic neoplasms. The incidence of pancreatic carcinomas was compared in groups of male and female mice fed one of three diets chosen because of their effect on the development of pancreatic carcinomas in other animal models. Male mice developed more exocrine carcinomas than female mice and their tumors were larger. Groups fed chow had fewer exocrine carcinomas than groups fed purified diets. The level of fat in the latter diets, 5 versus 20% corn oil, did not alter tumor incidence. An unexpectedly high incidence of islet cell tumors was found in all dietary groups, with a higher incidence in females than in males.

¹ Supported by NIH Grants CA 47327 and CA23108.

² To whom requests for reprints should be addressed, at Department of Pathology, Dartmouth Medical School, Hanover, NH 03756.

Received 5/22/90. Accepted 8/16/90.