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Deletion of -, ß-, and -Interferon Genes in Malignant Cells from Children with Acute Lymphocytic Leukemia¹

Division of Experimental Oncology, Radiumhemmet [S. E., D. G.], Department of Pediatrics [O. B., S. S.], and Department of Clinical Genetics [K. B-N.], Karolinska Hospital, 104 01 Stockholm, Sweden

Scanning densitometry and restriction fragment length polymorphism analysis were used to study the -, ß-, -, and -interferon (IFN) genes in malignant cells from 11 children with acute lymphocytic leukemia and in one cell line of T-cell origin. In the malignant cells of one patient there was a complete loss of -, ß-, and -IFN genes, whereas in another patient one of the alleles of these genes had been deleted. Cytogenetic analysis revealed a deletion of the short arm of chromosome 9, i.e., the region containing the -, ß-, and -IFN genes, in the latter patient. The normal cells of the patients with IFN gene deletions had two alleles of the -, ß-, and -IFN genes. In cells from none of the patients could deletions or rearrangements of the -IFN genes be detected. We conclude that in 2 of 11 patients with acute lymphocytic leukemia the malignant transformation is accompanied by loss of material on one or both chromosomes 9 and that the -, ß-, and -IFN genes are included in these deletions.

¹ This study was supported by grants from the King Gustav V Jubilee Foundation, the Swedish Society for Cancer Research, and Sällskapet Barnavård.

² To whom requests for reprints should be addressed.

Received 3/13/90. Accepted 8/31/90.

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