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Radioimmunodetection in Rhabdo- and Leiomyosarcoma with ¹¹¹In-Anti-Myosin Monoclonal Antibody Complex¹

Department of Medical Oncology, Rotterdam Cancer Institute, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands

In patients with rhabdo- and leiomyosarcoma a radioimmunodiagnostic study was performed with ¹¹¹In labeled F(ab) fragments of a monoclonal antibody against myosin. Eight patients with rhabdomyosarcoma and 18 patients with leiomyosarcoma were studied. Scanning was performed at 4, 24, and 48 h after administration of 74 MBeq of the antibody complex. A high uptake with a tumor:background ratio of 10:1 was observed in several patients with rhabdomyosarcoma but the results were less accurate in leiomyosarcoma.