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Independent Prognostic Value of Laminin Receptor Expression in Breast Cancer Survival

Ludwig Institute for Cancer Research, São Paulo Branch [L. A. M., E. L. F. F., H. T., R. R. B.]; Laboratório de Oncologia Experimental, Departamento de Clinica Médica-FMUSP [L. A. M., M. M. B.]; and Departamento de Mastologia do Hospital A. C. Camargo [J. B. S-N.], São Paulo, Brazil

We studied the possible prognostic role of laminin, estrogen (ER), and progesterone (PR) receptors and other pathological factors in relation to the disease-free interval and overall survival of female breast carcinoma patients. Multivariate analyses of clinical and pathological data with respect to the above survival time variables were performed by Cox regression. The statistical dependence of prognosis on ER, PR, and tumor size was based on the discriminant cutoff value that could best distinguish between survival curves. Axillary nodal status was the most significant independent factor in the prediction of both disease-free interval and overall survival of these patients. Use of the information on laminin receptor expression, PR concentration, tumor size, lymphocytic infiltrate, and tumor necrosis improved significantly the prediction of the risk of recurrence. Patients with tumors expressing laminin receptors had 40% less risk of recurrence (P = 0.0209) than those with no expression. On the other hand, four covariates were independently predictive of the risk of death: axillary nodal status, lymphocytic infiltrate, PR and ER concentration. There was a marginally significant (10% level) interaction between tumor size and lymphocytic infiltrate with respect to the prediction of the risk of recurrence. The above sets of variables were used to classify patients into risk groups for the prediction of recurrence and death.

¹ Recipient of a graduate fellowship from FAPESP (84/2752-5).

² Present address: Institut Armand-Frappier, Université du Québec, Laval, Quebec, Canada.

³ To whom requests for reprints should be addressed, at Epidemiology and Biostatistics Unit, Ludwig Institute for Cancer Research, Rua Prof. Antonio Prudente, 109, 01509 São Paulo, Brazil.

Received 7/21/89. Revised 10/30/89. Accepted 11/27/89.

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