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Chromosome Analysis of 31 Wilms' Tumors¹

Departments of Human Genetics [S. W-W., S. S., B. G.], Pathology [K. B.], and Hematology/Oncology [B. L.], Children's Hospital Medical Center, Cincinnati, Ohio 45229

Cytogenetic analysis was done on 31 Wilms' tumors, including 2 renal tumors of clear cell sarcoma type, using short term cultures of primary tumors and/or nude mouse passages. Nonrandom secondary chromosome abnormalities, in particular, were noted as evidence of clonal evolution. Apparently normal karyotypes were found in 5 Wilms' tumors, all in patients 22 months old, and in one clear cell sarcoma. Abnormal karyotypes were seen in 25 tumors (80%); 6 were pseudodiploid, 3 were hypodiploid, and 16 (52%) were hyperdiploid, of which 8 had a modal number of 47–49 and 8 had a modal number of 50–55. Nonrandom structural abnormalities involved 1p/1q, 11p, 7p/7q, 16p/16q, 12q, and 17p/17q. Nonrandom numerical abnormalities included +6, +8, and +18. Trisomy 12 was the most common abnormality, structural or numerical, seen in 52% of tumors (81% of the hyperdiploid). In 2 tumors the +12 was the only apparent abnormality; in 1 other tumor an i(12q) was seen, suggesting that +12 may have special significance in the clonal progression of Wilms' tumor. Informative karyotypes of 68 Wilms' tumors from other reports were reviewed and compared to results in this series.

¹ This work was supported by funds donated by Robert D. Lindner for Tumor Research and Phi Beta Psi Sorority. Investigators in Childrens Cancer Study Group contributed seven tumor samples. CCSG Grant 13539.

² To whom requests for reprints should be addressed, at Children's Hospital Medical Center, Elland and Bethesda Avenues, Cincinnati, OH 45229.

Received 9/ 6/89. Revised 1/ 8/90.

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