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Urinary Excretion of Nitrate, N-Nitrosoproline, 3-Methyladenine, and 7-Methylguanine in a Colombian Population at High Risk for Stomach Cancer¹

Division of Toxicology [W. G. S., J. G., H-X. X., J. S. W., S. R. T.] and Department of Chemistry [S. R. T.], Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; Department of Pathology, Louisiana State University, Medical Center, New Orleans, Louisiana 70112 [D. Z., P. C.]; and Departmento de Patologia, Facultad de Medicina, Universidad del Valle, Cali, [G. M.] Colombia

Urinary excretion levels of nitrate and N-nitrosoproline were determined in 160 individuals in a Colombian population at high risk for gastric cancer. In 156 of these subjects urinary levels of 3-methyladenine and 7-methylguanine were determined. Gastric biopsy specimens were obtained from 118 individuals and were histologically characterized according to pathological criteria into the following groups: normal, superficial gastritis, chronic atrophic gastritis, chronic atrophic gastritis with intestinal metaplasia, and dysplastic. The histological changes were correlated with the four variables listed above. There were no significant differences in the excretion of nitrate, N-nitrosoproline, 3-methyladenine, or 7-methylguanine in subjects with different pathological changes. A statistically significant correlation was present between nitrate and N-nitrosoproline excretion in the total population group (r = 0.297, P = 0.0001). A highly significant correlation (r = 0.56, P = 0.0002) was noted for urinary nitrate and N-nitrosoproline excretion in individuals with intestinal metaplasia and dysplasia. An increase in the urinary excretion of 3-methyladenine and 7-methylguanine was associated with tobacco smoking in the total population group.

¹ This investigation was supported by PHS Grants No. P01-CA26731, P30-ES02109 and P01-CA28842 from the National Cancer Institute, DHHS.

² To whom requests for reprints should be addressed, at Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 56-311, Cambridge, MA 02139.

Received 7/12/90. Accepted 10/ 9/90.

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