| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of Pathology, SM-30, University of Washington, Seattle, Washington 98195
Evidence suggests that a tumor behaves, in its pattern of growth, like an integrated organ rather than a collection of independently growing cells. Tumor growth tends to slow progressively as size increases and to undergo compensatory growth after partial resection. Consequently, therapies that reduce tumor mass may tend to accelerate the growth of the remaining tumor and tumor metastases. An approach to therapy based upon a simulated increase in tumor mass may be worthy of consideration.
Received 7/26/90. Accepted 10/ 5/90.
This article has been cited by other articles:
|
|
 |
|
  H. Enderling, A. R.A. Anderson, M. A.J. Chaplain, A. Beheshti, L. Hlatky, and P. Hahnfeldt Paradoxical Dependencies of Tumor Dormancy and Progression on Basic Cell Kinetics Cancer Res., November 15, 2009; 69(22): 8814 - 8821. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Vaupel and L. Harrison Tumor Hypoxia: Causative Factors, Compensatory Mechanisms, and Cellular Response Oncologist, November 1, 2004; 9(suppl_5): 4 - 9. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hata, R. Fujiwaki, K. Nakayama, and K. Miyazaki Expression of the Endostatin Gene in Epithelial Ovarian Cancer Clin. Cancer Res., August 1, 2001; 7(8): 2405 - 2409. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hockel and P. Vaupel Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects J Natl Cancer Inst, February 21, 2001; 93(4): 266 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Feldman, L. Tamarkin, G. F. Paciotti, B. W. Simpson, W. M. Linehan, J. C. Yang, W. E. Fogler, E. M. Turner, H. R. Alexander Jr., and S. K. Libutti Serum Endostatin Levels Are Elevated and Correlate with Serum Vascular Endothelial Growth Factor Levels in Patients with Stage IV Clear Cell Renal Cancer Clin. Cancer Res., December 1, 2000; 6(12): 4628 - 4634. [Abstract] [Full Text]
|
|
|
|
|
|
A. C. Hartford, T. Gohongi, D. Fukumura, and R. K. Jain Irradiation of a Primary Tumor, Unlike Surgical Removal, Enhances Angiogenesis Suppression at a Distal Site: Potential Role of Host-Tumor Interaction Cancer Res., April 1, 2000; 60(8): 2128 - 2131. [Abstract] [Full Text]
|
|
|
|
|
|
S. Ramanujan, G. C. Koenig, T. P. Padera, B. R. Stoll, and R. K. Jain Local Imbalance of Proangiogenic and Antiangiogenic Factors: A Potential Mechanism of Focal Necrosis and Dormancy in Tumors Cancer Res., March 1, 2000; 60(5): 1442 - 1448. [Abstract] [Full Text]
|
|
|
|
|
|
R. T. Prehn On the Prevention and Therapy of Prostate Cancer by Androgen Administration Cancer Res., September 1, 1999; 59(17): 4161 - 4164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Dong, J. Yoneda, R. Kumar, and I. J. Fidler Angiostatin-mediated Suppression of Cancer Metastases by Primary Neoplasms Engineered to Produce Granulocyte/Macrophage Colony-stimulating Factor J. Exp. Med., August 17, 1998; 188(4): 755 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. V. Volpert, J. Lawler, and N. P. Bouck A human fibrosarcoma inhibits systemic angiogenesis and the growth of experimental metastases via thrombospondin-1 PNAS, May 26, 1998; 95(11): 6343 - 6348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Fueyo, C. Gomez-Manzano, W.K.A. Yung, T. J. Liu, R. Alemany, J. M. Bruner, S. K. Chintala, J. S. Rao, V. A. Levin, and A. P. Kyritsis Suppression of human glioma growth by adenovirus-mediated Rb gene transfer Neurology, May 1, 1998; 50(5): 1307 - 1315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.S. O'Reilly, L. Holmgren, Y. Shing, C. Chen, R.A. Rosenthal, Y. Cao, M. Moses, W.S. Lane, E.H. Sage, and J. Folkman Angiostatin: A Circulating Endothelial Cell Inhibitor That Suppresses Angiogenesis and Tumor Growth Cold Spring Harb Symp Quant Biol, January 1, 1994; 59(0): 471 - 482. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Bayly, N. French, C Dive, and R. Roberts Non-genotoxic hepatocarcinogenesis in vitro: the FaO hepatoma line responds to peroxisome proliferators and retains the ability to undergo apoptosis J. Cell Sci., January 2, 1993; 104(2): 307 - 315. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
