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Cytogenetic Profile of 109 Lipomas¹

The Cancer Center of Genetrix, Scottsdale, Arizona 85251 [C. S., A. A. S.]; The Arizona Cancer Center [S. P. L. L., D. L. M., H. V.], Departments of Surgery [S. P. L. L., W. D. R., H. V.] and Biostatistics [D. L. M.], University of Arizona College of Medicine, Tucson, Arizona 85724; Roswell Park Memorial Institute, Buffalo, New York 14263 [C. P. K.]; Cigna Healthplan of Arizona, Tucson, Arizona 85712 [D. N., S. F., A. W.]; Tucson Medical Center, Tucson, Arizona 85712 [R. C.]; and Thomas-Davis Clinic, Tucson, Arizona 85711 [P. N. H.]

Cytogenetic analysis of short-term cultures was carried out on 109 lipomas from 92 patients. Clonal chromosomal abnormalities were present in 50% of the tumors analyzed. Based on the results, three main cytogenetic groups were identified and included: (a) tumors with normal karyotypes, (b) tumors with abnormalities involving region q13–15 on chromosome 12, and (c) tumors with other clonal aberrations. Within each of these groups, cytogenetic subgroups could be identified, each characterized by a specific anomaly. Tumors with abnormalities of 12q included specific subgroups with t/ins(1;12)(p32–33;q13–15), t(2;12)(p21–22;q13–14), t(3;12)(q28;q14), t(12;21)(q13;q21), complex, and nonrecurrent aberrations. The group containing heterogeneous clonal aberrations included subgroups with del(13)(q12q22), der(6)(p21–23), der(11)(q13), and nonspecific aberrations. Chromosome bands 1p36, 1p32–33, 2p21–22, 3q27–28, 6p21–23, 11q13, 12q13–15, 13q12, 13q22, 17p13, 17q21, and 21q21–22 were preferentially involved in structural rearrangements in lipomas. The identification of these sites of nonrandom rearrangements may serve to identify genes (at or near the junctions of chromosomal aberrations) involved in normal cellular growth control. Statistical analysis of the data revealed a correlation among karyotypic abnormalities and clinical data, such as age and sex of the patient, and tumor depth, site, and size.

¹ Financial support: Grant CA-41183 from the National Cancer Institute.

² Present address: Kidwai Memorial Institute of Oncology, Hosur Road, Bangalose 560 029, India.

³ Recipient of the American Cancer Society Clinical Oncology Career Award, 1987–1990.

⁴ To whom requests for reprints should be addressed, at The Cancer Center of Southwest Biomedical Research, Institute of Genetrix, 6401 East Thomas Road, Scottsdale, AZ 85251.

Received 7/23/90. Accepted 10/ 1/90.

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