This Article Full Text (PDF) Correction (v51,p5008) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Walz, T. M. Articles by Wasteson, A. Search for Related Content PubMed PubMed Citation Articles by Walz, T. M. Articles by Wasteson, A.

Suramin Inhibits Growth of Human Osteosarcoma Xenografts in Nude Mice¹

Departments of Cell Biology [T. M. W., A. A., Å. W.], Oncology [S. W.]; General Surgery [S. S.], and Orthopaedic Surgery [S-E. L.], Faculty of Health Sciences, University of Linkoping, S-581 85 Linkoping, Sweden

The effect of suramin on tumor growth and morphology in two different human osteosarcoma xenografts (L-I OSM and L-II OSM) grown in BALB/cA-nu/nu mice was studied. Suramin (total dose, 720 mg/kg) given by i.p. injection (60 mg/kg/dose) for up to 9 weeks significantly inhibited osteosarcoma cell growth in both tumors, suramin-treated tumors showing only one-third or less of the volume of nontreated controls. Cell cycle distribution of tumor cells measured by DNA flow cytometry demonstrated that suramin treatment caused accumulation of cells in the S and G₂ phases of the cell cycle, in both L-I OSM and L-II OSM. In the aneuploid L-II OSM tumor suramin preferentially inhibited the growth of aneuploid cells, leading to a decrease in the ratio of aneuploid to diploid cells. Both osteosarcomas retained their histological appearance and the liver, spleen, heart, and kidneys of the treated animals were unaffected by suramin. These results are compatible with the view that suramin inhibits the growth of human osteosarcomas by cytostatic effects.

¹ Supported by grants from The Swedish Medical Research Council (4486) and Östgötaregionens Cancer Fond.

² To whom requests for reprints should be addressed, at Department of Cell Biology, Faculty of Health Sciences, University of Linköping, S-581 85 Linköping, Sweden.

Received 2/ 4/91. Accepted 4/22/91.

This article has been cited by other articles:

				C. Cahlin, A. Körner, H. Axelsson, W. Wang, K. Lundholm, and E. Svanberg Experimental Cancer Cachexia: The Role of Host-derived Cytokines Interleukin (IL)-6, IL-12, Interferon-{{gamma}}, and Tumor Necrosis Factor {{alpha}} Evaluated in Gene Knockout, Tumor-bearing Mice on C57 Bl Background and Eicosanoid-dependent Cachexia Cancer Res., October 1, 2000; 60(19): 5488 - 5493. [Abstract] [Full Text]