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Transplantation of Human Prostatic Carcinoma into Nude Mice in Matrigel¹

Institute of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106

Previous successful transplantation of human primary prostatic carcinomas into nude mice has been described as "close to zero." When injected in Matrigel instead of culture medium, 25,000-fold fewer cells of the PC-3 human prostatic carcinoma cell line were required for the growth of tumors in nude mice during a 3-month period of observation; similar enhancement was observed with two other human prostatic carcinoma cell lines. Six of ten primary human prostatic carcinomas were transplanted successfully into nude mice when Matrigel was used as the vehicle.

¹ This work was supported by NIH Grants CA48032, CA43703, and CA54031; Grant PDT-407 from the American Cancer Society; and Grant 89B48 from the American Institute for Cancer Research.

² To whom requests for reprints should be addressed.

Received 4/22/91. Accepted 5/29/91.

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