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The Human Gene Encoding Phosphatidylinositol-3 Kinase Associated p85 Is at Chromosome Region 5q12–13¹

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140 [L. A. C., C. M. C., K. H.], and Department of Pharmacology, New York University Medical Center, New York, New York 10016 [E. Y. S., B. M., J. S.]

The human chromosomal location of the gene encoding the phosphatidylinositol-3 kinase associated protein, p85, has been determined by analysis of its segregation in rodent-human hybrids and by chromosome in situ hybridization using a complementary DNA clone, GRB-1.

The gene for p85 is at chromosome region 5q13, perhaps near the gene encoding another receptor associated signal transducing protein, the GTPase activating protein.

¹ This work was supported by NIH Grants CA21124 and CA39860.

² To whom requests for reprints should be addressed, at Jefferson Cancer Center, Thomas Jefferson University, 233 S. 10^th St., Phila., PA 19107-5541.

Received 5/13/91. Accepted 5/28/91.