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Chromosome Locations of the MYB Related Genes, AMYB and BMYB¹

Raggio Italgene, Pomezia, Italy [C. B.]; Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140 [T. D., S. L., B. C., C. M. C., K. H.]; and Eleanor Roosevelt Institute, Denver, Colorado 80206 [H. D., D. P.]

The MYB related loci, AMYB and BMYB, were localized to specific human chromosome regions by Southern blot analysis of their segregation patterns in a panel of rodent-human hybrid DNAs using radiolabeled AMYB and BMYB probes. The AMYB locus was present in hybrids retaining the chromosome region 8cen8q22 and was absent in hybrids which had lost this chromosome region. The presence of the BMYB locus in rodent-human hybrids correlated with, and only with, chromosome region Xq13. Chromosomal in situ hybridization refined the localization of AMYB to region 8q22–23 and confirmed the localization of BMYB to region Xq13. Chromosome region 8q22 is involved in recurrent translocations in malignant lymphoma and in acute myeloid leukemia (AML-M2); therefore AMYB is a candidate for involvement in such translocations. A region on Xq13 is also involved in chromosomal abnormalities in acute myeloid leukemia and myelodysplasias.

¹ Supported by NIH Grants CA21124, CA39860, and HD17449.

² To whom requests for reprints should be addressed, at Jefferson Cancer Institute, Thomas Jefferson University, 233 S. 10^th St., Philadelphia, PA 19107-5541.

Received 4/17/91. Accepted 5/29/91.

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