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Preferential Expression of the dbl Protooncogene in Some Tumors of Neuroectodermal Origin¹

Centro di Endocrinologia e Oncologia Sperimentale del CNR, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare "L. Califano," Università di Napoli, Via S. Pansini 5, 80131 Naples, Italy [V. d. F., R. R., G. L. C-D., G. V.], and Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892 [A. E.]

We have investigated the expression of the dbl protooncogene in a wide variety of human tumors of different embryological derivation. We found that proto-dbl mRNA could be detected preferentially in a few neoplastic histiotypes of neuroectodermal origin. The common, normal 5-kilobase size of the proto-dbl transcript detected indicated that the proto-dbl in these tumors was not rearranged. These data, in agreement with our previous reports, suggest that the dbl protooncogene is expressed in a highly tissue-specific manner and indicate that this gene may be involved in the growth and differentiation of some cells of neuroectodermal origin.

¹ This work was supported by the Associazione Italiana per la Ricerca sul Cancro, by the CNR Target Project "Biotechnology and Bioinstrumentation," and by the "Progetto AIDS" of the Ministero Italiano della Sanità. G. L. C-D. is a recipient of a fellowship from the Associazione Italiana per la Ricerca sul Cancro.

² To whom requests for reprints should be addressed.

Received 1/28/91. Accepted 6/10/91.

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