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Accumulation of m-Iodobenzylguanidine by Neuroblastoma Cells Results from Independent Uptake and Storage Mechanisms¹

Pediatric Oncology Research Laboratory, G. Gaslini Children's Hospital, Genoa, Italy

The modalities of uptake and storage of iodine-labeled m-iodobenzylguanidine (MIBG) by four human neuroblastoma cell lines have been studied. SK-N-BE(2)C cell line has been shown to possess the specific (type 1) MIBG uptake, as well as an efficient extravesicular storage mechanism. Conversely, LAN-5 cells, which show a nonsaturation kinetic of MIBG incorporation, lack only the ability to efficiently store the MIBG taken up by a mechanism that can be pharmacologically defined as uptake 1. The two other neuroblastoma cell lines tested, GI-LI-N and GI-CA-N, lack both uptake and storage capacity.

In view of the fact that the only detailed study on specific MIBG uptake by a human neuroblastoma cell line has been carried out on SK-N-SH, a highly heterogeneous cell line, our report provides new insights on the molecular and cellular pharmacology of radiolabeled MIBG.

¹ Supported by Ricerca Corrente Gaslini Grant N 901702C and Associazione Italiana per la Ricerca sul Cancro, Milan, Italy.

² To whom requests for reprints should be addressed, at Pediatric Oncology Research Laboratory, G. Gaslini Institute, Largo Gerolamo Gaslini 5, 16148 Genoa, Italy.

Received 3/25/91. Accepted 6/10/91.

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