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Hypoxic Fractions in Xenografted Human Colon Tumors¹

Brown University Radiation Research Laboratories, Department of Radiation Medicine, Providence, Rhode Island 02912 [J. T. L., G. P., L. F.], and Syntex Corporation, Palo Alto, California 94303 [S. M.]

We investigated the percentage of radiobiologically hypoxic cells within 11 different xenografted human colon tumors using an in vivo-in vitro excision assay technique. Tumors were excised at average volumes of 750 mm³, and it was found that hypoxic fractions varied from less than 1% (clone D) to over 80% (HCT-8). The geometric mean hypoxic percentage was 10.4% (95% confidence interval, 4.9 to 22.1%). Comparison of the percentage of hypoxia results from the xenografted human colon tumors to published data from xenografted melanomas suggests that transplanted colorectal tumors as a class contain significantly less hypoxia than do the melanomas.

¹ Research supported by NIH Grant CA 50350 from the National Cancer Institute.

² To whom requests for reprints should be addressed, at Brown University, Division of Biology and Medicine, Box G, Rm B-003, Providence, RI 02912.

Received 5/ 6/91. Accepted 7/19/91.

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