| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Departments of Epidemiology [K. N., K. I.] and Biochemistry [S-i. H., J. W., K. K.], Saitama Cancer Center Research Institute, 818 Komuro, Ina-machi, Saitama 362, Japan
Cytochrome P450IA1 is responsible for the metabolic activation of benzo(a)pyrene in cigarette smoke; an association of lung cancer with DNA polymorphisms of P450IA1 gene was shown in our previous study.
In this paper, we investigated the interindividual difference of genetically determined susceptibility to squamous cell carcinoma of the lung in relation to cigarette smoking dose. We first compared the total amounts of cigarettes consumed over the lifetime of patients and showed that the patients with a "susceptible" P450IA1 gene genotype contracted carcinoma after fewer cigarettes [mean ± SD, 31.3 ± 12.8 x 104 cigarettes (n = 12)] than those with other genotypes [42.5 ± 18.2 x 104 (n = 33)], with a statistical significance of P < 0.05. Next, we carried out a casecontrol study to estimate the odds ratios of susceptible to nonsusceptible individuals in relation to the cumulate cigarette dose. We thus showed that the individuals with the susceptible genotype were at remarkably high risk with an odds ratio of 7.31 (95% confidence interval, 2.13 to 25.12) at a low dose level of cigarette smoking and that the difference in susceptibility between genotypes was reduced at high dose levels.
1 Supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan and by a research grant from the Ministry of Health and Welfare of Japan.
2 To whom requests for reprints should be addressed.
Received 12/12/90. Accepted 7/19/91.
This article has been cited by other articles:
|
|
 |
|
  S. Wang, S. Chanock, D. Tang, Z. Li, W. Jedrychowski, and F. P. Perera Assessment of Interactions between PAH Exposure and Genetic Polymorphisms on PAH-DNA Adducts in African American, Dominican, and Caucasian Mothers and Newborns Cancer Epidemiol. Biomarkers Prev., February 1, 2008; 17(2): 405 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-i. Nitadori, M. Inoue, M. Iwasaki, T. Otani, S. Sasazuki, K. Nagai, S. Tsugane, and the JPHC Study Group Association Between Lung Cancer Incidence and Family History of Lung Cancer: Data From a Large-Scale Population-Based Cohort Study, the JPHC Study. Chest, October 1, 2006; 130(4): 968 - 975. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Y. Park, J. M. Park, J. S. Jang, J. E. Choi, K. M. Kim, S. I. Cha, C. H. Kim, Y. M. Kang, W. K. Lee, S. Kam, et al. Caspase 9 promoter polymorphisms and risk of primary lung cancer Hum. Mol. Genet., June 15, 2006; 15(12): 1963 - 1971. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. F. Masson, L. Sharp, S. C. Cotton, and J. Little Cytochrome P-450 1A1 Gene Polymorphisms and Risk of Breast Cancer: A HuGE Review Am. J. Epidemiol., May 15, 2005; 161(10): 901 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.L. Cote, S.L.R. Kardia, A.S. Wenzlaff, S.J. Land, and A.G. Schwartz Combinations of glutathione S-transferase genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study Carcinogenesis, April 1, 2005; 26(4): 811 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H Esfandiary, U Chakravarthy, C Patterson, I Young, and A E Hughes Association study of detoxification genes in age related macular degeneration Br. J. Ophthalmol., April 1, 2005; 89(4): 470 - 474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Georgiadis, J. Topinka, D. Vlachodimitropoulos, M. Stoikidou, M. Gioka, G. Stephanou, H. Autrup, N. A. Demopoulos, K. Katsouyanni, R. Sram, et al. Interactions between CYP1A1 polymorphisms and exposure to environmental tobacco smoke in the modulation of lymphocyte bulky DNA adducts and chromosomal aberrations Carcinogenesis, January 1, 2005; 26(1): 93 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ito, K. Matsuo, N. Hamajima, T. Mitsudomi, T. Sugiura, T. Saito, T. Yasue, K.-M. Lee, D. Kang, K.-Y. Yoo, et al. Gene-environment interactions between the smoking habit and polymorphisms in the DNA repair genes, APE1 Asp148Glu and XRCC1 Arg399Gln, in Japanese lung cancer risk Carcinogenesis, August 1, 2004; 25(8): 1395 - 1401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Wang, W. Tan, B. Hao, X. Miao, G. Zhou, F. He, and D. Lin Substantial Reduction in Risk of Lung Adenocarcinoma Associated with Genetic Polymorphism in CYP2A13, the Most Active Cytochrome P450 for the Metabolic Activation of Tobacco-Specific Carcinogen NNK Cancer Res., November 15, 2003; 63(22): 8057 - 8061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-S. Jeon, K. M. Kim, S. H. Park, S. Y. Lee, J. E. Choi, G. Y. Lee, S. Kam, R. W. Park, I.-S. Kim, C. H. Kim, et al. Relationship between XPG codon 1104 polymorphism and risk of primary lung cancer Carcinogenesis, October 1, 2003; 24(10): 1677 - 1681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K J Syrjanen HPV infections and lung cancer J. Clin. Pathol., December 1, 2002; 55(12): 885 - 891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. Park, S. Y. Lee, H.-S. Jeon, N. C. Bae, S. C. Chae, S. Joo, C. H. Kim, J.-H. Park, S. Kam, I. S. Kim, et al. Polymorphism of the DNA Repair Gene XRCC1 and Risk of Primary Lung Cancer Cancer Epidemiol. Biomarkers Prev., January 1, 2002; 11(1): 23 - 27. [Abstract] [Full Text]
|
|
|
|
|
|
G. B. J. Smith, P. A. Harper, J. M. Y. Wong, M. S. M. Lam, K. R. Reid, D. Petsikas, and T. E. Massey Human Lung Microsomal Cytochrome P4501A1 (CYP1A1) Activities: Impact of Smoking Status and CYP1A1, Aryl Hydrocarbon Receptor, and Glutathione S-Transferase M1 Genetic Polymorphisms Cancer Epidemiol. Biomarkers Prev., August 1, 2001; 10(8): 839 - 853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sarmanova, K. Benesova, I. Gut, V. Nedelcheva-Kristensen, L. Tynkova, and P. Soucek Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin's and non-Hodgkin's lymphomas Hum. Mol. Genet., June 1, 2001; 10(12): 1265 - 1273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Schwarz, P. Kisselev, I. Cascorbi, W.-H. Schunck, and I. Roots Differential metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 variants Carcinogenesis, March 1, 2001; 22(3): 453 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Song, W. Tan, D. Xing, and D. Lin CYP 1A1 polymorphism and risk of lung cancer in relation to tobacco smoking: a case-control study in China Carcinogenesis, January 1, 2001; 22(1): 11 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wang, D. Chen, T. Niu, Z. Wang, L. Wang, L. Ryan, T. Smith, D. C. Christiani, B. Zuckerman, and X. Xu Genetic Susceptibility to Benzene and Shortened Gestation: Evidence of Gene-Environment Interaction Am. J. Epidemiol., October 15, 2000; 152(8): 693 - 700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Inoue, C. Kiyohara, T. Marugame, S. Shinomiya, E. Tsuji, K. Handa, H. Hayabuchi, K. Onuma, H. Hamada, H. Koga, et al. Cigarette Smoking, CYP1A1 MspI and GSTM1 Genotypes, and Colorectal Adenomas Cancer Res., July 1, 2000; 60(14): 3749 - 3752. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. G. Shields and C. C. Harris Cancer Risk and Low-Penetrance Susceptibility Genes in Gene-Environment Interactions J. Clin. Oncol., June 11, 2000; 18(11): 2309 - 2315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-C. Hong, H.-S. Park, and E.-H. Ha Influence of genetic susceptibility on the urinary excretion of 8-hydroxydeoxyguanosine of firefighters Occup. Environ. Med., June 1, 2000; 57(6): 370 - 375. [Abstract] [Full Text]
|
|
|
|
|
|
H. Bartsch, U. Nair, A. Risch, M. Rojas, H. Wikman, and K. Alexandrov Genetic Polymorphism of CYP Genes, Alone or in Combination, as a Risk Modifier of Tobacco-related Cancers Cancer Epidemiol. Biomarkers Prev., January 1, 2000; 9(1): 3 - 28. [Abstract] [Full Text]
|
|
|
|
 |
|
 W. P. Bennett, M. C. R. Alavanja, B. Blomeke, K. H. Vahakangas, K. Castren, J. A. Welsh, E. D. Bowman, M. A. Khan, D. B. Flieder, and C. C. Harris Environmental Tobacco Smoke, Genetic Susceptibility, and Risk of Lung Cancer in Never-Smoking Women J Natl Cancer Inst, December 1, 1999; 91(23): 2009 - 2014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sato, T. Sato, T. Izumo, and T. Amagasa Genetic polymorphism of drug-metabolizing enzymes and susceptibility to oral cancer Carcinogenesis, October 1, 1999; 20(10): 1927 - 1931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shimada, J. Watanabe, K. Kawajiri, T. R. Sutter, F. P. Guengerich, E. M.J. Gillam, and K. Inoue Catalytic properties of polymorphic human cytochrome P450 1B1 variants Carcinogenesis, August 1, 1999; 20(8): 1607 - 1614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. M. van Lieshout, H. M. J. Roelofs, S. Dekker, C. J. J. Mulder, T. Wobbes, J. B. M. J. Jansen, and W. H. M. Peters Polymorphic Expression of the Glutathione Polymorphic Expression of the Glutathione S-Transferase P1 Gene and Its Susceptibility to Barrett's Esophagus and Esophageal Carcinoma Cancer Res., February 1, 1999; 59(3): 586 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Lai and P. G. Shields The Role of Interindividual Variation in Human Carcinogenesis J. Nutr., February 1, 1999; 129(2): 552 - 552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Romano, A. Sgambato, A. Boninsegna, G. Flamini, G. Curigliano, Q. Yang, V. La Gioia, C. Signorelli, A. Ferro, G. Capelli, et al. Evaluation of Polycyclic Aromatic Hydrocarbon-DNA Adducts in Exfoliated Oral Cells by an Immunohistochemical Assay Cancer Epidemiol. Biomarkers Prev., January 1, 1999; 8(1): 91 - 96. [Abstract] [Full Text]
|
|
|
|
 |
|
 F. P. Perera Environment and Cancer: Who Are Susceptible? Science, November 7, 1997; 278(5340): 1068 - 1073. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. W. Linder, R. A. Prough, and R. Valdes Jr. Pharmacogenetics: a laboratory tool for optimizing therapeutic efficiency Clin. Chem., February 1, 1997; 43(2): 254 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Imai and K Nakachi Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases BMJ, March 18, 1995; 310(6981): 693 - 696. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
