| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
NeoRx Corporation, Seattle, Washington 98119
A 186Re-labeled monoclonal antibody (MAb), NR-LU-10, was used for the radioimmunotherapy of a subcutaneous human small cell lung carcinoma xenograft, SHT-1, in nude mice. Biodistribution with specific and irrelevant labeled MAb demonstrated peak tumor uptake of 8% and 3% of the injected dose/g at 2 days, respectively. Dosimetry analysis predicted tumor:whole-body radiation-absorbed dose ratios of 2.43:1 for NR-LU-10 and 0.62:1 for irrelevant MAb. Single-dose toxicity screening estimated a 50% lethal dose within 30 days of 600 µCi (880 cGy of whole-body radiation). As anticipated, a multiple-dose regimen of 490 µCi in four doses over 10 days (720 cGy of whole-body radiation, eight of eight surviving >30 days) was less toxic than a single bolus dose of 430 µCi (644 cGy of whole-body radiation), six of eight surviving >30 days). A multidose radioimmunotherapy regimen was initiated in nude mice bearing 66-mm3 tumors (total dose, 500 to 600 µCi). Complete remissions (>140 days) were achieved in three of 16 mice, and the remainder showed a mean tumor growth delay of 53 days. Matched doses with irrelevant MAb produced one remission, one treatment-related death, and a mean growth delay of only 20 days in six of eight mice. Thus, in this nonoptimal radioimmunotherapy model, significant antitumor responses were observed using a mildly toxic multiple dosing regimen.
1 To whom requests for reprints should be addressed, at NeoRx Corporation, 410 W. Harrison, Seattle, WA 98119.
Received 6/12/90. Accepted 10/26/90.
This article has been cited by other articles:
|
|
 |
|
  H. R. Nordlund, V. P. Hytonen, O. H. Laitinen, and M. S. Kulomaa Novel Avidin-like Protein from a Root Nodule Symbiotic Bacterium, Bradyrhizobium japonicum J. Biol. Chem., April 8, 2005; 280(14): 13250 - 13255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Pagel, N. Hedin, K. Subbiah, D. Meyer, R. Mallet, D. Axworthy, L. J. Theodore, D. S. Wilbur, D. C. Matthews, and O. W. Press Comparison of anti-CD20 and anti-CD45 antibodies for conventional and pretargeted radioimmunotherapy of B-cell lymphomas Blood, March 15, 2003; 101(6): 2340 - 2348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. W. Press, M. Corcoran, K. Subbiah, D. K. Hamlin, D. S. Wilbur, T. Johnson, L. Theodore, E. Yau, R. Mallett, D. L. Meyer, et al. A comparative evaluation of conventional and pretargeted radioimmunotherapy of CD20-expressing lymphoma xenografts Blood, October 15, 2001; 98(8): 2535 - 2543. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Axworthy, J. M. Reno, M. D. Hylarides, R. W. Mallett, L. J. Theodore, L. M. Gustavson, F.-M. Su, L. J. Hobson, P. L. Beaumier, and A. R. Fritzberg Cure of human carcinoma xenografts by a single dose of pretargeted yttrium-90 with negligible toxicity PNAS, February 15, 2000; 97(4): 1802 - 1807. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Knox, M. L. Goris, M. Tempero, P. L. Weiden, L. Gentner, H. Breitz, G. P. Adams, D. Axworthy, S. Gaffigan, K. Bryan, et al. Phase II Trial of Yttrium-90-DOTA-Biotin Pretargeted by NR-LU-10 Antibody/Streptavidin in Patients with Metastatic Colon Cancer Clin. Cancer Res., February 1, 2000; 6(2): 406 - 414. [Abstract] [Full Text]
|
|
|
|
|
|
G. Pavlinkova, B. J. M. Booth, S. K. Batra, and D. Colcher Radioimmunotherapy of Human Colon Cancer Xenografts Using a Dimeric Single-Chain Fv Antibody Construct Clin. Cancer Res., September 1, 1999; 5(9): 2613 - 2619. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
