This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Applegate, L. A. Articles by Tyrrell, R. M. Search for Related Content PubMed PubMed Citation Articles by Applegate, L. A. Articles by Tyrrell, R. M.

Induction of Heme Oxygenase: A General Response to Oxidant Stress in Cultured Mammalian Cells¹

Swiss Institute for Experimental Cancer Research, Cell Mutation Unit, CH-1066 Epalinges, Switzerland

Accumulation of heme oxygenase mRNA is strongly stimulated by treatment of cultured human skin fibroblasts with ultraviolet radiation, hydrogen peroxide, or the sulfhydryl reagent sodium arsenite (S. M. Keyse and R. M. Tyrrell. Proc. Natl. Acad. Sci. USA, 86: 99–103, 1989). Since this will result in a transient reduction in the prooxidant state of cells, the phenomenon may represent an important inducible antioxidant defense mechanism. To examine the generality of the response, we have measured the accumulation of the specific mRNA in a variety of human and mammalian cell types after inducing treatments. Induction by sodium arsenite is observed in all additional human cell types tested. This includes primary epidermal keratinocytes and lung and colon fibroblasts as well as established cell lines such as HeLa, TK6 lymphoblastoid, and transformed fetal keratinocytes. Strong induction of heme oxygenase mRNA is also observed following sodium arsenite treatment of cell lines of rat, hamster, mouse, monkey, and marsupial origin. The agents which lead to induction in cultured human skin fibroblasts fall into two categories: (a) those which are oxidants or can generate active intermediates (ultraviolet A radiation, hydrogen peroxide, menadione, and the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate); (b) agents which are known to interact with or modify cellular glutathione levels (buthionine sulfoximine, sodium arsenite, iodoacetamide, diamide, and cadmium chloride). These observations strongly support the hypothesis that induction of the enzyme is a general response to oxidant stress in mammalian cells and are consistent with the possibility that the cellular redox state plays a key role.

¹ The work reported in this paper was supported by grants from the Swiss National Science Foundation (3.186.088) and the Swiss League Against Cancer and was undertaken during the tenure of a Research Training Fellowship to L. A. A. by the International Agency for Research on Cancer.

² To whom requests for reprints should be addressed.

Received 9/13/90. Accepted 11/20/90.

This article has been cited by other articles:

				S. W. Ryter and A. M. K. Choi Heme Oxygenase-1/Carbon Monoxide: From Metabolism to Molecular Therapy Am. J. Respir. Cell Mol. Biol., September 1, 2009; 41(3): 251 - 260. [Abstract] [Full Text] [PDF]

				G Valacchi, A Pecorelli, M Mencarelli, E Maioli, and P. Davis Beta-carotene prevents ozone-induced proinflammatory markers in murine skin Toxicology and Industrial Health, May 1, 2009; 25(4-5): 241 - 247. [Abstract] [PDF]

				A. L. Yu, J. Moriniere, M. Birke, C. Neumann, R. Fuchshofer, A. Kampik, H. Bloemendal, and U. Welge-Lussen Reactivation of Optic Nerve Head Astrocytes by TGF-{beta}2 and H2O2 Is Accompanied by Increased Hsp32 and Hsp47 Expression Invest. Ophthalmol. Vis. Sci., April 1, 2009; 50(4): 1707 - 1717. [Abstract] [Full Text] [PDF]

				H. Ozkan, H. Oren, M. Tatli, H. Ates, A. Kumral, and N. Duman Erythroid Apoptosis in Idiopathic Neonatal Jaundice Pediatrics, May 1, 2008; 121(5): e1348 - e1351. [Abstract] [Full Text] [PDF]

				L. Wang, J.-Y. S. Lee, J. H. Kwak, Y. He, S. I. Kim, and M. E. Choi Protective effects of low-dose carbon monoxide against renal fibrosis induced by unilateral ureteral obstruction Am J Physiol Renal Physiol, March 1, 2008; 294(3): F508 - F517. [Abstract] [Full Text] [PDF]

				A. T. Black, J. P. Gray, M. P. Shakarjian, D. L. Laskin, D. E. Heck, and J. D. Laskin Distinct effects of ultraviolet B light on antioxidant expression in undifferentiated and differentiated mouse keratinocytes Carcinogenesis, January 1, 2008; 29(1): 219 - 225. [Abstract] [Full Text] [PDF]

				Z. Yang, S. Yang, S. Y. Qian, J.-S. Hong, M. B. Kadiiska, R. W. Tennant, M. P. Waalkes, and J. Liu Cadmium-Induced Toxicity in Rat Primary Mid-brain Neuroglia Cultures: Role of Oxidative Stress from Microglia Toxicol. Sci., August 1, 2007; 98(2): 488 - 494. [Abstract] [Full Text] [PDF]

				Q. Lin, S. Weis, G. Yang, Y.-H. Weng, R. Helston, K. Rish, A. Smith, J. Bordner, T. Polte, F. Gaunitz, et al. Heme Oxygenase-1 Protein Localizes to the Nucleus and Activates Transcription Factors Important in Oxidative Stress J. Biol. Chem., July 13, 2007; 282(28): 20621 - 20633. [Abstract] [Full Text] [PDF]

				L. D. Orozco, M. H. Kapturczak, B. Barajas, X. Wang, M. M. Weinstein, J. Wong, J. Deshane, S. Bolisetty, Z. Shaposhnik, D. M. Shih, et al. Heme Oxygenase-1 Expression in Macrophages Plays a Beneficial Role in Atherosclerosis Circ. Res., June 22, 2007; 100(12): 1703 - 1711. [Abstract] [Full Text] [PDF]

				S. H. Lam, C. L. Winata, Y. Tong, S. Korzh, W. S. Lim, V. Korzh, J. Spitsbergen, S. Mathavan, L. D. Miller, E. T. Liu, et al. Transcriptome kinetics of arsenic-induced adaptive response in zebrafish liver Physiol Genomics, November 21, 2006; 27(3): 351 - 361. [Abstract] [Full Text] [PDF]

				A. Kamijo-Ikemori, T. Sugaya, A. Obama, J. Hiroi, H. Miura, M. Watanabe, T. Kumai, R. Ohtani-Kaneko, K. Hirata, and K. Kimura Liver-Type Fatty Acid-Binding Protein Attenuates Renal Injury Induced by Unilateral Ureteral Obstruction Am. J. Pathol., October 1, 2006; 169(4): 1107 - 1117. [Abstract] [Full Text] [PDF]

				W.-C. Lo, P.-J. Lu, W.-Y. Ho, M. Hsiao, and C.-J. Tseng Induction of Heme Oxygenase-1 Is Involved in Carbon Monoxide-Mediated Central Cardiovascular Regulation J. Pharmacol. Exp. Ther., July 1, 2006; 318(1): 8 - 16. [Abstract] [Full Text] [PDF]

				S. W. Ryter, J. Alam, and A. M. K. Choi Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications Physiol Rev, April 1, 2006; 86(2): 583 - 650. [Abstract] [Full Text] [PDF]

				K. Devadas and S. Dhawan Hemin Activation Ameliorates HIV-1 Infection via Heme Oxygenase-1 Induction J. Immunol., April 1, 2006; 176(7): 4252 - 4257. [Abstract] [Full Text] [PDF]

				L. Wu and R. Wang Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications Pharmacol. Rev., December 1, 2005; 57(4): 585 - 630. [Abstract] [Full Text] [PDF]

				A. Sollwedel, A. Z. Bertoja, M. L. Zenclussen, K. Gerlof, U. Lisewski, P. Wafula, B. Sawitzki, C. Woiciechowsky, H.-D. Volk, and A. C. Zenclussen Protection from Abortion by Heme Oxygenase-1 Up-Regulation Is Associated with Increased Levels of Bag-1 and Neuropilin-1 at the Fetal-Maternal Interface J. Immunol., October 15, 2005; 175(8): 4875 - 4885. [Abstract] [Full Text] [PDF]

				F McArdle, S Spiers, H Aldemir, A Vasilaki, A Beaver, L Iwanejko, A McArdle, and M. J Jackson Preconditioning of skeletal muscle against contraction-induced damage: the role of adaptations to oxidants in mice J. Physiol., November 15, 2004; 561(1): 233 - 244. [Abstract] [Full Text] [PDF]

				R. Stocker and J. F. Keaney Jr. Role of Oxidative Modifications in Atherosclerosis Physiol Rev, October 1, 2004; 84(4): 1381 - 1478. [Abstract] [Full Text] [PDF]

				R. N. Pires Das Neves, F. Carvalho, M. Carvalho, E. Fernandes, E. Soares, M. D. L. Bastos, and M. D. L. Pereira Protective Activity of Hesperidin and Lipoic Acid Against Sodium Arsenite Acute Toxicity in Mice Toxicol Pathol, August 1, 2004; 32(5): 527 - 535. [Abstract] [PDF]

				W. T. Johnson and L. C. S. DeMars Increased Heme Oxygenase-1 Expression during Copper Deficiency in Rats Results from Increased Mitochondrial Generation of Hydrogen Peroxide J. Nutr., June 1, 2004; 134(6): 1328 - 1333. [Abstract] [Full Text] [PDF]

				M. Alvarez-Maqueda, R. E. Bekay, G. Alba, J. Monteseirin, P. Chacon, A. Vega, J. Martin-Nieto, F. J. Bedoya, E. Pintado, and F. Sobrino 15-Deoxy-{Delta}12,14-prostaglandin J2 Induces Heme Oxygenase-1 Gene Expression in a Reactive Oxygen Species-dependent Manner in Human Lymphocytes J. Biol. Chem., May 21, 2004; 279(21): 21929 - 21937. [Abstract] [Full Text] [PDF]

				P. A.A.S. Navarro, L. Liu, and D. L. Keefe In Vivo Effects of Arsenite on Meiosis, Preimplantation Development, and Apoptosis in the Mouse Biol Reprod, April 1, 2004; 70(4): 980 - 985. [Abstract] [Full Text] [PDF]

				E. M. Sikorski, T. Hock, N. Hill-Kapturczak, and A. Agarwal The story so far: molecular regulation of the heme oxygenase-1 gene in renal injury Am J Physiol Renal Physiol, March 1, 2004; 286(3): F425 - F441. [Abstract] [Full Text] [PDF]

				S. Y. Park, I. Chang, J.-Y. Kim, S. W. Kang, S.-H. Park, K. Singh, and M.-S. Lee Resistance of Mitochondrial DNA-depleted Cells against Cell Death: ROLE OF MITOCHONDRIAL SUPEROXIDE DISMUTASE J. Biol. Chem., February 27, 2004; 279(9): 7512 - 7520. [Abstract] [Full Text] [PDF]

				Y.-H. Weng, G. Yang, S. Weiss, and P. A. Dennery Interaction between Heme Oxygenase-1 and -2 Proteins J. Biol. Chem., December 19, 2003; 278(51): 50999 - 51005. [Abstract] [Full Text] [PDF]

				R. Zegdi, O. Fabre, N. Lila, P. Fornes, M. Cambillau, M. Shen, P. Herve, A. Carpentier, and J.-N. Fabiani Exhaled carbon monoxide and inducible heme oxygenase expression in a rat model of postperfusion acute lung injury J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 1867 - 1874. [Abstract] [Full Text] [PDF]

				F. A. D. T. G. Wagener, H.-D. Volk, D. Willis, N. G. Abraham, M. P. Soares, G. J. Adema, and C. G. Figdor Different Faces of the Heme-Heme Oxygenase System in Inflammation Pharmacol. Rev., September 1, 2003; 55(3): 551 - 571. [Abstract] [Full Text] [PDF]

				K. Robert, J.-F. Chasse, D. Santiard-Baron, C. Vayssettes, A. Chabli, J. Aupetit, N. Maeda, P. Kamoun, J. London, and N. Janel Altered Gene Expression in Liver from a Murine Model of Hyperhomocysteinemia J. Biol. Chem., August 22, 2003; 278(34): 31504 - 31511. [Abstract] [Full Text] [PDF]

				T. Kietzmann, A. Samoylenko, and S. Immenschuh Transcriptional Regulation of Heme Oxygenase-1 Gene Expression by MAP Kinases of the JNK and p38 Pathways in Primary Cultures of Rat Hepatocytes J. Biol. Chem., May 9, 2003; 278(20): 17927 - 17936. [Abstract] [Full Text] [PDF]

				S. Grasso, C. Scifo, V. Cardile, R. Gulino, and M. Renis Adaptive Responses to the Stress Induced by Hyperthermia or Hydrogen Peroxide in Human Fibroblasts Experimental Biology and Medicine, May 1, 2003; 228(5): 491 - 498. [Abstract] [Full Text] [PDF]

				C. Colombrita, V. Calabrese, A. M. G. Stella, F. Mattei, D. L. Alkon, and G. Scapagnini Regional Rat Brain Distribution of Heme Oxygenase-1 and Manganese Superoxide Dismutase mRNA: Relevance of Redox Homeostasis in the Aging Processes Experimental Biology and Medicine, May 1, 2003; 228(5): 517 - 524. [Abstract] [Full Text] [PDF]

				A. Ohlmann, S. Giffhorn-Katz, I. Becker, N. Katz, and S. Immenschuh Regulation of Heme Oxygenase-1 Gene Expression by Anoxia and Reoxygenation in Primary Rat Hepatocyte Cultures Experimental Biology and Medicine, May 1, 2003; 228(5): 584 - 589. [Abstract] [Full Text] [PDF]

				C Dani, E Martelli, G Bertini, M Pezzati, L Filippi, M Rossetti, G Rizzuti, and F F Rubaltelli Plasma bilirubin level and oxidative stress in preterm infants Arch. Dis. Child. Fetal Neonatal Ed., March 1, 2003; 88(2): F119 - F123. [Abstract] [Full Text] [PDF]

				E. Rydkina, A. Sahni, D. J. Silverman, and S. K. Sahni Rickettsia rickettsii Infection of Cultured Human Endothelial Cells Induces Heme Oxygenase 1 Expression Infect. Immun., August 1, 2002; 70(8): 4045 - 4052. [Abstract] [Full Text] [PDF]

				W. H. Miller Jr., H. M. Schipper, J. S. Lee, J. Singer, and S. Waxman Mechanisms of Action of Arsenic Trioxide Cancer Res., July 15, 2002; 62(14): 3893 - 3903. [Abstract] [Full Text] [PDF]

				B. H. J. Pannen New Insights Into the Regulation of Hepatic Blood Flow After Ischemia and Reperfusion Anesth. Analg., June 1, 2002; 94(6): 1448 - 1457. [Full Text] [PDF]

				R. L. Maser, D. Vassmer, B. S. Magenheimer, and J. P. Calvet Oxidant Stress and Reduced Antioxidant Enzyme Protection in Polycystic Kidney Disease J. Am. Soc. Nephrol., April 1, 2002; 13(4): 991 - 999. [Abstract] [Full Text] [PDF]

				R. Hori, M. Kashiba, T. Toma, A. Yachie, N. Goda, N. Makino, A. Soejima, T. Nagasawa, K. Nakabayashi, and M. Suematsu Gene Transfection of H25A Mutant Heme Oxygenase-1 Protects Cells against Hydroperoxide-induced Cytotoxicity J. Biol. Chem., March 15, 2002; 277(12): 10712 - 10718. [Abstract] [Full Text] [PDF]

				A. Rothfuss, P. Radermacher, and G. Speit Involvement of heme oxygenase-1 (HO-1) in the adaptive protection of human lymphocytes after hyperbaric oxygen (HBO) treatment Carcinogenesis, December 1, 2001; 22(12): 1979 - 1985. [Abstract] [Full Text] [PDF]

				F. TAMION, V. RICHARD, G. BONMARCHAND, J. LEROY, J.-P. LEBRETON, and C. THUILLEZ Induction of Heme-oxygenase-1 Prevents the Systemic Responses to Hemorrhagic Shock Am. J. Respir. Crit. Care Med., November 15, 2001; 164(10): 1933 - 1938. [Abstract] [Full Text] [PDF]

				P. Silacci, A. Desgeorges, L. Mazzolai, C. Chambaz, and D. Hayoz Flow Pulsatility Is a Critical Determinant of Oxidative Stress in Endothelial Cells Hypertension, November 1, 2001; 38(5): 1162 - 1166. [Abstract] [Full Text] [PDF]

				M. Alizadeh, M. Wada, C. M. Gelfman, J. T. Handa, and L. M. Hjelmeland Downregulation of Differentiation Specific Gene Expression by Oxidative Stress in ARPE-19 Cells Invest. Ophthalmol. Vis. Sci., October 1, 2001; 42(11): 2706 - 2713. [Abstract] [Full Text] [PDF]

				C. E. Clayton, M. S. Carraway, H. B. Suliman, E. D. Thalmann, K. N. Thalmann, D. E. Schmechel, and C. A. Piantadosi Inhaled carbon monoxide and hyperoxic lung injury in rats Am J Physiol Lung Cell Mol Physiol, October 1, 2001; 281(4): L949 - L957. [Abstract] [Full Text] [PDF]

				R. B. Hunter, H. Mitchell-Felton, D. A. Essig, and S. C. Kandarian Expression of endoplasmic reticulum stress proteins during skeletal muscle disuse atrophy Am J Physiol Cell Physiol, October 1, 2001; 281(4): C1285 - C1290. [Abstract] [Full Text] [PDF]

				S. Hadjur, K. Ung, L. Wadsworth, J. Dimmick, E. Rajcan-Separovic, R. W. Scott, M. Buchwald, and F. R. Jirik Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase Blood, August 15, 2001; 98(4): 1003 - 1011. [Abstract] [Full Text] [PDF]

				J. B. Wijeweera, A. J. Gandolfi, A. Parrish, and R. C. Lantz Sodium Arsenite Enhances AP-1 and NF{{kappa}} B DNA Binding and Induces Stress Protein Expression in Precision-Cut Rat Lung Slices Toxicol. Sci., June 1, 2001; 61(2): 283 - 294. [Abstract] [Full Text] [PDF]

				J. Liu, M. B. Kadiiska, Y. Liu, T. Lu, W. Qu, and M. P. Waalkes Stress-Related Gene Expression in Mice Treated with Inorganic Arsenicals Toxicol. Sci., June 1, 2001; 61(2): 314 - 320. [Abstract] [Full Text] [PDF]

				T. Ulyanova, A. Szél, R. K. Kutty, B. Wiggert, A. R. Caffé, G. J. Chader, and T. van Veen Oxidative Stress Induces Heme Oxygenase-1 Immunoreactivity in Muller Cells of Mouse Retina in Organ Culture Invest. Ophthalmol. Vis. Sci., May 1, 2001; 42(6): 1370 - 1374. [Abstract] [Full Text]

				P. A. Dennery The Biology of Heme Oxygenase During Development NeoReviews, March 1, 2001; 2(3): e67 - 73. [Full Text]

				S. X. Liu, M. Athar, I. Lippai, C. Waldren, and T. K. Hei Induction of oxyradicals by arsenic: Implication for mechanism of genotoxicity PNAS, February 1, 2001; (2001) 31482998. [Abstract] [Full Text]

				M Cavicchi, L Gibbs, and B J R Whittle Inhibition of inducible nitric oxide synthase in the human intestinal epithelial cell line, DLD-1, by the inducers of heme oxygenase 1, bismuth salts, heme, and nitric oxide donors Gut, December 1, 2000; 47(6): 771 - 778. [Abstract] [Full Text] [PDF]

				L. S. Marton, X. Wang, A. Kowalczuk, Z.-D. Zhang, E. Windmeyer, and R. L. Macdonald Effects of hemoglobin on heme oxygenase gene expression and viability of cultured smooth muscle cells Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2405 - H2413. [Abstract] [Full Text] [PDF]

				P. J. Lee, S. L. Camhi, B. Y. Chin, J. Alam, and A. M. K. Choi AP-1 and STAT mediate hyperoxia-induced gene transcription of heme oxygenase-1 Am J Physiol Lung Cell Mol Physiol, July 1, 2000; 279(1): L175 - L182. [Abstract] [Full Text] [PDF]

				P. PAREDI, S. A. KHARITONOV, D. LEAK, P. L. SHAH, D. CRAMER, M. E. HODSON, and P. J. BARNES Exhaled Ethane Is Elevated in Cystic Fibrosis and Correlates with Carbon Monoxide Levels and Airway Obstruction Am. J. Respir. Crit. Care Med., April 1, 2000; 161(4): 1247 - 1251. [Abstract] [Full Text]

				S. Immenschuh, V. Hinke, N. Katz, and T. Kietzmann Transcriptional Induction of Heme Oxygenase-1 Gene Expression by Okadaic Acid in Primary Rat Hepatocyte Cultures Mol. Pharmacol., March 1, 2000; 57(3): 610 - 618. [Abstract] [Full Text]

				M. V. Panchenko, H. W. Farber, and J. H. Korn Induction of heme oxygenase-1 by hypoxia and free radicals in human dermal fibroblasts Am J Physiol Cell Physiol, January 1, 2000; 278(1): C92 - C101. [Abstract] [Full Text] [PDF]

				Q. di Wu, J. H. Wang, F. Fennessy, H. P. Redmond, and D. Bouchier-Hayes Taurine prevents high-glucose-induced human vascular endothelial cell apoptosis Am J Physiol Cell Physiol, December 1, 1999; 277(6): C1229 - C1238. [Abstract] [Full Text] [PDF]

				F. A. D. T. G. Wagener, J.-L. da Silva, T. Farley, T. de Witte, A. Kappas, and N. G. Abraham Differential Effects of Heme Oxygenase Isoforms on Heme Mediation of Endothelial Intracellular Adhesion Molecule 1 Expression J. Pharmacol. Exp. Ther., October 1, 1999; 291(1): 416 - 423. [Abstract] [Full Text]

				P. Paredi, W. Biernacki, G. Invernizzi, S. A. Kharitonov, and P. J. Barnes Exhaled Carbon Monoxide Levels Elevated in Diabetes and Correlated With Glucose Concentration in Blood: A New Test for Monitoring the Disease? Chest, October 1, 1999; 116(4): 1007 - 1011. [Abstract] [Full Text] [PDF]

				D. M. SUTTNER and P. A. DENNERY Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron FASEB J, October 1, 1999; 13(13): 1800 - 1809. [Abstract] [Full Text]

				P Paredi, P L Shah, P Montuschi, P Sullivan, M E Hodson, S A Kharitonov, and P J Barnes Increased carbon monoxide in exhaled air of patients with cystic fibrosis Thorax, October 1, 1999; 54(10): 917 - 920. [Abstract] [Full Text]

				M. S. Iordanov and B. E. Magun Different Mechanisms of c-Jun NH2-terminal Kinase-1 (JNK1) Activation by Ultraviolet-B Radiation and by Oxidative Stressors J. Biol. Chem., September 3, 1999; 274(36): 25801 - 25806. [Abstract] [Full Text] [PDF]

				C. Barlow, P. A. Dennery, M. K. Shigenaga, M. A. Smith, J. D. Morrow, L. J. Roberts II, A. Wynshaw-Boris, and R. L. Levine Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs PNAS, August 17, 1999; 96(17): 9915 - 9919. [Abstract] [Full Text] [PDF]

				L. Yang, S. Quan, and N. G. Abraham Retrovirus-mediated HO gene transfer into endothelial cells protects against oxidant-induced injury Am J Physiol Lung Cell Mol Physiol, July 1, 1999; 277(1): L127 - L133. [Abstract] [Full Text] [PDF]

				C. M. Terry, J. A. Clikeman, J. R. Hoidal, and K. S. Callahan TNF-alpha and IL-1alpha induce heme oxygenase-1 via protein kinase C, Ca2+, and phospholipase A2 in endothelial cells Am J Physiol Heart Circ Physiol, May 1, 1999; 276(5): H1493 - H1501. [Abstract] [Full Text] [PDF]

				D. M. Suttner, K. Sridhar, C. S. Lee, T. Tomura, T. N. Hansen, and P. A. Dennery Protective effects of transient HO-1 overexpression on susceptibility to oxygen toxicity in lung cells Am J Physiol Lung Cell Mol Physiol, March 1, 1999; 276(3): L443 - L451. [Abstract] [Full Text] [PDF]

				T. Oguro, M. Hayashi, S. Nakajo, S. Numazawa, and T. Yoshida The Expression of Heme Oxygenase-1 Gene Responded to Oxidative Stress Produced by Phorone, a Glutathione Depletor, in the Rat Liver; The Relevance to Activation of c-Jun N-Terminal Kinase J. Pharmacol. Exp. Ther., November 1, 1998; 287(2): 773 - 778. [Abstract] [Full Text]

				M. Mietus-Snyder, C. K. Glass, and R. E. Pitas Transcriptional Activation of Scavenger Receptor Expression in Human Smooth Muscle Cells Requires AP-1/c-Jun and C/EBPß : Both AP-1 Binding and JNK Activation Are Induced by Phorbol Esters and Oxidative Stress Arterioscler Thromb Vasc Biol, September 1, 1998; 18(9): 1440 - 1449. [Abstract] [Full Text] [PDF]

				G. W. De Keulenaer, D. C. Chappell, N. Ishizaka, R. M. Nerem, R. W. Alexander, and K. K. Griendling Oscillatory and Steady Laminar Shear Stress Differentially Affect Human Endothelial Redox State : Role of a Superoxide-Producing NADH Oxidase Circ. Res., June 1, 1998; 82(10): 1094 - 1101. [Abstract] [Full Text] [PDF]

				K. K. Elbirt, A. J. Whitmarsh, R. J. Davis, and H. L. Bonkovsky Mechanism of Sodium Arsenite-mediated Induction of Heme Oxygenase-1 in Hepatoma Cells. ROLE OF MITOGEN-ACTIVATED PROTEIN KINASES J. Biol. Chem., April 10, 1998; 273(15): 8922 - 8931. [Abstract] [Full Text] [PDF]

				S. Immenschuh, T. Kietzmann, V. Hinke, M. Wiederhold, N. Katz, and U. Muller-Eberhard The Rat Heme Oxygenase-1 Gene Is Transcriptionally Induced via the Protein Kinase A Signaling Pathway in Rat Hepatocyte Cultures Mol. Pharmacol., March 1, 1998; 53(3): 483 - 491. [Abstract] [Full Text]

				J. F. Reckelhoff, V. Kanji, L. C. Racusen, A. M. Schmidt, S. Du Yan, J. Morrow, L. J. Roberts II, and A. K. Salahudeen Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1998; 274(3): R767 - R774. [Abstract] [Full Text] [PDF]

				C. M. Terry, J. A. Clikeman, J. R. Hoidal, and K. S. Callahan Effect of tumor necrosis factor-alpha and interleukin-1alpha on heme oxygenase-1 expression in human endothelial cells Am J Physiol Heart Circ Physiol, March 1, 1998; 274(3): H883 - H891. [Abstract] [Full Text] [PDF]

				S. L. Camhi, J. Alam, G. W. Wiegand, B. Y. Chin, and A. M. K. Choi Transcriptional Activation of the HO-1 Gene by Lipopolysaccharide Is Mediated by 5' Distal Enhancers: Role of Reactive Oxygen Intermediates and AP-1 Am. J. Respir. Cell Mol. Biol., February 1, 1998; 18(2): 226 - 234. [Abstract] [Full Text]

				R. F. Hamilton Jr., L. Li, W. L. Eschenbacher, L. Szweda, and A. Holian Potential involvement of 4-hydroxynonenal in the response of human lung cells to ozone Am J Physiol Lung Cell Mol Physiol, January 1, 1998; 274(1): L8 - L16. [Abstract] [Full Text] [PDF]

				R. Foresti, J. E. Clark, C. J. Green, and R. Motterlini Thiol Compounds Interact with Nitric Oxide in Regulating Heme Oxygenase-1 Induction in Endothelial Cells. INVOLVEMENT OF SUPEROXIDE AND PEROXYNITRITE ANIONS J. Biol. Chem., July 18, 1997; 272(29): 18411 - 18417. [Abstract] [Full Text] [PDF]

				M. Mietus-Snyder, A. Friera, C. K. Glass, and R. E. Pitas Regulation of Scavenger Receptor Expression in Smooth Muscle Cells by Protein Kinase C: A Role for Oxidative Stress Arterioscler Thromb Vasc Biol, May 1, 1997; 17(5): 969 - 978. [Abstract] [Full Text]

				W. Durante, M. H. Kroll, N. Christodoulides, K. J. Peyton, and A. I. Schafer Nitric Oxide Induces Heme Oxygenase-1 Gene Expression and Carbon Monoxide Production in Vascular Smooth Muscle Cells Circ. Res., April 19, 1997; 80(4): 557 - 564. [Abstract] [Full Text]

				T. Oguro, E. Kaneko, S. Numazawa, S. Imaoka, Y. Funae, and T. Yoshida Induction of Hepatic Heme Oxygenase and Changes in Cytochrome P-450s in Response to Oxidative Stress Produced by Stilbenes and Stilbene Oxides in Rats J. Pharmacol. Exp. Ther., March 1, 1997; 280(3): 1455 - 1462. [Abstract] [Full Text]

				S. A. Lee, A. Dritschilo, and M. Jung Role of ATM in Oxidative Stress-mediated c-Jun Phosphorylation in Response to Ionizing Radiation and CdCl2 J. Biol. Chem., April 6, 2001; 276(15): 11783 - 11790. [Abstract] [Full Text] [PDF]

				S. X. Liu, M. Athar, I. Lippai, C. Waldren, and T. K. Hei Induction of oxyradicals by arsenic: Implication for mechanism of genotoxicity PNAS, February 13, 2001; 98(4): 1643 - 1648. [Abstract] [Full Text] [PDF]