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Decreased Levels of 1,2-sn-Diacylglycerol in Human Colon Tumors¹

Departments of Medicine [S-C. P., I. B. W.] and Surgery [M. M., J. G. G., P. L.] and the Comprehensive Cancer Center and Institute of Cancer Research [I. B. W.], Columbia-Presbyterian Medical Center of Columbia University, New York, New York 10032, and the Yakult Institute for Microbiological Research, 1796 Yaho, Kunitachi, 186 Tokyo, Japan [M. M.]

We have found that in 15 of 15 primary human colon tumors there was a significant decrease (by about 40%) in the levels of diacyglycerol when compared to paired adjacent normal mucosa samples. Assays on the same samples indicated that this decrease was seen both in tumors that did and did not display mutations in codon 12 of c-K-ras. These results, taken together with previous studies on protein kinase C, suggest that the protein kinase C signal transduction pathway is suppressed in human colon cancer.

¹ This research was supported by an award to Columbia University from the Yakult Honsha Company, Tokyo (to P. L.) and from the Aaron Diamond Foundation, New York (to I. B. W.).

² Present address: Department of Medicine, Room S102C, Stanford University Medical Center, Stanford, CA 94304.

³ To whom requests for reprints should be addressed, at Comprehensive Cancer Center and Institute of Cancer Research, Columbia-Presbyterian Medical Center of Columiba University, 701 West 168th St., New York, NY 10032.

Received 12/11/90. Accepted 1/17/91.

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