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Molecular Cloning of the Chromosomal Breakpoint of a B-Cell Lymphoma with the t(11;14)(q23;q32) Translocation¹

Laboratories of Chemotherapy and Immunology, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya 464, Japan [Y. A., M. S., T. T., R. U.]; Department of Medicine, Kochi Medical School, Kochi 781-51, Japan [I. K., I. M.]; Department of Pediatrics, Yamanashi Medical College, Nakakoma-gun, Yamanashi 409-38, Japan [S. N.]; The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104 [Y. T.]; and The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140 [C. M. C.]

The breakpoint of t(11;14)(q23;q32) chromosome translocation in a B-cell lymphoma line, RC-K8, was cloned. Immunoglobulin heavy chain (IGH) constant gene, C2 at the 5' end, was involved in this translocation, and the DNA segment juxtaposed to the C2 was proved to be derived from chromosome 11 by somatic cell hybrid study. The normal counterpart of chromosome 11 was also isolated. With a DNA probe near the breakpoint of chromsome 11, Southern blot analysis of RC-K8 and 10 other cases with translocation involving the 11q23 region was conducted, but no rearrangement bands have been observed thus far except for RC-K8.

¹ This work was supported in part by a Grant-in-Aid for the comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health and Welfare; a Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture, Japan; a grant from the Cancer Research Institute Inc., New York; and by Grant CA 39860 from the National Cancer Institute (C. M. C.).

² To whom requests for reprints should be addressed.

Received 12/17/90. Accepted 1/17/91.

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