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Division of Hematology-Oncology, Department of Medicine, and the Jonsson Comprehensive Cancer Center, University of California, Los Angeles, School of Medicine, Los Angeles, California 90024 [T. S., D. J. S.]; Department of Urology, University of Düsseldorf, 4000-Düsseldorf, Germany [T. S., S. P., R. A.]; Department of Urology, Armed Forces Hospital, 2000-Hamburg, Germany [M. H.]; Department of Molecular Biology, Max-Planck-Institute for Biochemistry, 8033-Martinsried, Germany [S. M., A. U.]; and CETUS Corporation, Department of Molecular Biology, Emeryville, California 94608 [S. M.]
Seventy testicular germ cell tumors were analyzed at the DNA and RNA levels for the c-kit, hst-1, and int-2 oncogenes using Northern and Southern blot analyses, respectively. There were significant differences in oncogene expression between seminomas and nonseminomas with c-kit being expressed in 24 of 30 (80%) seminomas but in only 3 of 40 (7%) nonseminomatous tumors (P = 0.0001, x2 test) and hst-1 being expressed in 24 of 38 (63%) nonseminomas but only 1 of 24 (4%) of seminomas (P= 0.0001, x2 test), demonstrating an inverse relationship in the expression pattern of these 2 oncogenes in human testicular germ cell tumors. A significant association between tumor stage and hst-1 expression in the nonseminoma group was found (P = 0.0002, x2 test). No gross alterations in the c-kit, hst-1, and int-2 loci were found at the DNA level and no int-2 mRNA expression was detected in any of the germ cell tumors examined.
1 This work was supported by USPHS Grant CA 36827. T.S. is supported by grants from Deutscher Akademischer Austauschdienst (312 402 698 9) and Deutsche Forschungsgemeinschaft (Str. 270/2-1). D.J.S. is supported by American Cancer Society Grant FRA 323.
2 To whom requests for reprints should be addressed, at Hematology-Oncology, UCLA School of Medicine, 11-259 Factor Building, Los Angeles, CA 90024.
Received 8/22/90. Accepted 1/21/91.
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