| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of Oncology, Ospedale S. Giovanni Vecchio, 10123 Turin, Italy [M. R., G. L. C., A. B., S. C., F. P. R.], and Memorial Sloan-Kettering Cancer Center, New York, New York [M. L.]
An in vitro study of proliferative activity as shown by immunohistochemical detection of the uptake of bromodeoxyuridine was run on rectal biopsies from 400 patients with nonfamilial large bowel neoplasia: 200 adenoma; 150 adenocarcinoma; 50 adenoma plus adenocarcinoma. The controls were 400 subjects with negative personal and family histories of colorectal neoplasia. The number and height distribution of bromodeoxyuridine positive cells were determined by dividing the crypt into five longitudinal compartments. The total labeling index and the labeling index of each compartment were higher in all three groups compared with the controls. In subjects with adenoma, total labeling index and labeling index values were correlated with tumor size and decreased in function of the duration of the polyp-free colon state. The major zone of DNA synthesis had shifted to the intermediate and surface crypt compartments in all three groups. This stage II abnormality was more marked in adenoma patients with a high degree of dysplasia and in those with adenoma plus adenocarcinoma. Hyperproliferation and the proliferative compartment shift are cytokinetic abnormalities that coexist in the flat rectal mucosa of patients with colorectal neoplasia. Nonetheless, they are independent, controlled by different factors, and are expressions of different biological aspects of large bowel carcinogenesis.
1 To whom requests for reprints should be addressed.
Received 10/ 9/90. Accepted 1/24/91.
This article has been cited by other articles:
|
|
 |
|
  J. Kim, J. Ng, A. Arozulllah, R. Ewing, X. Llor, R. E. Carroll, and R. V. Benya Aberrant Crypt Focus Size Predicts Distal Polyp Histopathology Cancer Epidemiol. Biomarkers Prev., May 1, 2008; 17(5): 1155 - 1162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. K. Roy, D. P. Kunte, J. L. Koetsier, J. Hart, Y. L. Kim, Y. Liu, M. Bissonnette, M. Goldberg, V. Backman, and R. K. Wali Chemoprevention of colon carcinogenesis by polyethylene glycol: suppression of epithelial proliferation via modulation of SNAIL/{beta}-catenin signaling. Mol. Cancer Ther., August 1, 2006; 5(8): 2060 - 2069. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ferrand, C. Bertrand, G. Portolan, G. Cui, J. Carlson, L. Pradayrol, D. Fourmy, M. Dufresne, T. C. Wang, and C. Seva Signaling Pathways Associated with Colonic Mucosa Hyperproliferation in Mice Overexpressing Gastrin Precursors Cancer Res., April 1, 2005; 65(7): 2770 - 2777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Rittler, H. Demmelmair, B. Koletzko, K.-W. Jauch, and W. H. Hartl Effect of tumor removal on mucosal protein synthesis in patients with colorectal cancer Am J Physiol Endocrinol Metab, May 1, 2003; 284(5): E1018 - E1021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Wali, S. Khare, M. Tretiakova, G. Cohen, L. Nguyen, J. Hart, J. Wang, M. Wen, A. Ramaswamy, L. Joseph, et al. Ursodeoxycholic Acid and F6-D3 Inhibit Aberrant Crypt Proliferation in the Rat Azoxymethane Model of Colon Cancer: Roles of Cyclin D1 and E-Cadherin Cancer Epidemiol. Biomarkers Prev., December 1, 2002; 11(12): 1653 - 1662. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wacker, P. Wanek, E. Eder, S. Hylla, A. Gostner, and W. Scheppach Effect of Enzyme-resistant Starch on Formation of 1,N2-Propanodeoxyguanosine Adducts of trans-4-Hydroxy-2-nonenal and Cell Proliferation in the Colonic Mucosa of Healthy Volunteers Cancer Epidemiol. Biomarkers Prev., September 1, 2002; 11(9): 915 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Sellin, S. Umar, J. Xiao, and A. P. Morris Increased {beta}-Catenin Expression and Nuclear Translocation Accompany Cellular Hyperproliferation in Vivo Cancer Res., April 1, 2001; 61(7): 2899 - 2906. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. A. Weaver, C. T. Tangel, J. A. Krause, M. M. Parfitt, J. J. Stragand, P. L. Jenkins, T. A. Erb, R. H. Davidson, H. D. Alpern, W. B. Guiney Jr., et al. Biomarkers of Human Colonic Cell Growth Are Influenced Differently by a History of Colonic Neoplasia and the Consumption of Acarbose J. Nutr., November 1, 2000; 130(11): 2718 - 2725. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Umar, J. H. Sellin, and A. P. Morris Increased nuclear translocation of catalytically active PKC-zeta during mouse colonocyte hyperproliferation Am J Physiol Gastrointest Liver Physiol, July 1, 2000; 279(1): G223 - G237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Z. Hui, A. E. Noffsinger, M. A. Miller, P. Hurtubise, and C. M. Fenoglio-Preiser Strong Epidermal Growth Factor Receptor Expression But Not HER2/neu Expression Correlates with Cell Proliferation in Anal Canal Carcinomas International Journal of Surgical Pathology, October 1, 1999; 7(4): 193 - 203. [Abstract] [PDF]
|
|
|
|
 |
|
 S E Green, P Chapman, J Burn, A D Burt, M Bennett, D R Appleton, J S Varma, and J C Mathers Colonic epithelial cell proliferation in hereditary non-polyposis colorectal cancer Gut, July 1, 1998; 43(1): 85 - 92. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Renga, G Brandi, G M Paganelli, C Calabrese, S Papa, A Tosti, P Tomassetti, M Miglioli, and G Biasco Rectal cell proliferation and colon cancer risk in patients with hypergastrinaemia Gut, September 1, 1997; 41(3): 330 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N.J. Carr, M.A. Albahra, U.C. Nzeako, and L.H. Sobin Proliferating Cell Nuclear Antigen (PCNA) Immunoexpression in Hyperplastic Polyps and Adenomas of the Appendix International Journal of Surgical Pathology, April 1, 1995; 2(4): 275 - 280. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
