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Molecular Cloning and Chromosomal Mapping of a Human Galactoside-binding Protein¹

Cancer Metastasis Program [A. R., P. C., T. R., V. H.] and Cancer Genetics Program [A. M., S. R. W.], Michigan Cancer Foundation, Detroit, Michigan 48201

A human galactoside-binding protein with an M_r of 31,000 was cloned from the human HT-1080 fibrosarcoma complementary DNA library. A partial complementary DNA clone containing the complete coding region was characterized and the deduced sequence encodes a polypeptide of 242 amino acids with the characteristics of a carbohydrate-binding protein. The gene coding for the human galactoside-binding protein was mapped to the chromosomal band 1p13. The deduced amino acid sequence of the human galactoside-binding protein revealed 95 residues at the amino terminus, homologous to the predicted amino acid sequence of the second exon of the human L-myc gene.

¹ This work was supported by National Cancer Institute Grant CA-46120, by the Paul Zuckerman Support Foundation for Cancer Research to A. R., and by the Levy-Stone Program in Cancer Genetics.

² To whom requests for reprints should be addressed, at Michigan Cancer Foundation, 110 E. Warren Avenue, Detroit, MI 48201.

Received 10/11/90. Accepted 2/ 5/91.

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