| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Pathology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104 [Y. S., S. H.], and Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160 [Y. S.], Japan
The expression pattern of two Ca2+-dependent intercellular adhesion molecules, E- and P-cadherin, in 54 surgically resected gastric adenocarcinomas was examined immunohistochemically. E-cadherin was expressed uniformly at the cell-cell borders of most of the differentiated and adherent-type undifferentiated gastric adenocarcinomas, showing that E-cadherin serves as the main cadherin molecule responsible for intercellular binding in these carcinomas. Scattered-type undifferentiated gastric adenocarcinomas which apparently lacked this tight intercellular adhesion were divisible into two groups on the basis of E-cadherin expression. In a minor group composed of 4 carcinomas, E-cadherin could not be detected, suggesting that the absence of E-cadherin made the cancer cells separate. In contrast, cancer cells of 19 carcinomas which belonged to the major group showed similar scattering but had definite expression of E-cadherin on their cell surfaces, suggesting that there was some mechanism(s) disturbing the function of E-cadherin in these carcinomas. However, immunoblotting showed no evidence of gross alterations of the E-cadherin molecule, such as partial deletion, in these carcinomas. P-cadherin was expressed in 29 (54%) of the examined gastric carcinomas, and the expression was unstable in most of them, a characteristic feature compared with the stable expression of E-cadherin. Since P-cadherin is known to be expressed temporarily in the foregut during embryogenesis and was proved to be occasionally expressed, although weakly, in the proliferative zone of noncancerous gastric epithelial in this study, expression of P-cadherin in gastric carcinomas may be an oncofetal phenomenon and/or may reflect their marked proliferative potential.
1 This work was supported in part by a Grant-in-Aid from the Ministry of Health and Welfare of Japan for a Comprehensive 10-Year Strategy for Cancer Control.
2 Awardee of Research Resident Fellowship from the Foundation for Promotion of Cancer Research.
3 To whom requests for reprints should be addressed.
Received 10/25/90. Accepted 2/ 1/91.
This article has been cited by other articles:
|
|
 |
|
  K. HIBI, Y.-H. KITAMURA, H. MIZUKAMI, T. GOTO, K. SAKURABA, M. SAKATA, M. SAITO, K. ISHIBASHI, G. KIGAWA, H. NEMOTO, et al. Frequent CDH3 Demethylation in Advanced Gastric Carcinoma Anticancer Res, October 1, 2009; 29(10): 3945 - 3947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. HIBI, T. GOTO, H. MIZUKAMI, Y.-H. KITAMURA, K. SAKURABA, M. SAKATA, M. SAITO, K. ISHIBASHI, G. KIGAWA, H. NEMOTO, et al. Demethylation of the CDH3 Gene Is Frequently Detected in Advanced Colorectal Cancer Anticancer Res, June 1, 2009; 29(6): 2215 - 2217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Milicic, L.-A. Harrison, R. A. Goodlad, R. G. Hardy, A. M. Nicholson, M. Presz, O. Sieber, S. Santander, J. H. Pringle, N. Mandir, et al. Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission In vivo Cancer Res., October 1, 2008; 68(19): 7760 - 7768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Wheelock, Y. Shintani, M. Maeda, Y. Fukumoto, and K. R. Johnson Cadherin switching J. Cell Sci., March 15, 2008; 121(6): 727 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Oue, Y. Hamai, Y. Mitani, S. Matsumura, Y. Oshimo, P. P. Aung, K. Kuraoka, H. Nakayama, and W. Yasui Gene Expression Profile of Gastric Carcinoma: Identification of Genes and Tags Potentially Involved in Invasion, Metastasis, and Carcinogenesis by Serial Analysis of Gene Expression Cancer Res., April 1, 2004; 64(7): 2397 - 2405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Sugiyama, S. Dan, Y. Yoshida, F. Akiyama, K. Sugiyama, Y. Hirai, M. Matsuura, S. Miyata, M. Ushijima, K. Hasumi, et al. A Large-Scale Gene Expression Comparison of Microdissected, Small-Sized Endometrial Cancers with or without Hyperplasia Matched to Same-Patient Normal Tissue Clin. Cancer Res., November 15, 2003; 9(15): 5589 - 5600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nishimura, T. Saito, H. Yamasaki, and R. Kudo Suppression of gap junctional intercellular communication via 5' CpG island methylation in promoter region of E-cadherin gene in endometrial cancer cells Carcinogenesis, October 1, 2003; 24(10): 1615 - 1623. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. S. Choi, Y. M. Shim, S.-H. Kim, D. S. Son, H.-S. Lee, G. Y. Kim, J. Han, and J. Kim Prognostic significance of E-cadherin and {beta}-catenin in resected stage I non-small cell lung cancer Eur. J. Cardiothorac. Surg., September 1, 2003; 24(3): 441 - 449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Boussioutas, H. Li, J. Liu, P. Waring, S. Lade, A. J. Holloway, D. Taupin, K. Gorringe, I. Haviv, P. V. Desmond, et al. Distinctive Patterns of Gene Expression in Premalignant Gastric Mucosa and Gastric Cancer Cancer Res., May 15, 2003; 63(10): 2569 - 2577. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Smyth, O. Sheils, S. Finn, C. Martin, J. O'Leary, and E. C. Sweeney Real-time Quantitative Analysis of E-cadherin Expression in ret/PTC-1-Activated Thyroid Neoplasms International Journal of Surgical Pathology, October 1, 2001; 9(4): 265 - 272. [Abstract] [PDF]
|
|
|
|
|
|
J. W. Slaton, T. Karashima, P. Perrotte, K. Inoue, S. J. Kim, J. Izawa, D. Kedar, D. J. McConkey, R. Millikan, P. Sweeney, et al. Treatment with Low-Dose Interferon-{alpha} Restores the Balance between Matrix Metalloproteinase-9 and E-Cadherin Expression in Human Transitional Cell Carcinoma of the Bladder Clin. Cancer Res., September 1, 2001; 7(9): 2840 - 2853. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Grotzinger, J Kneifel, D Patschan, N Schnoy, I Anagnostopoulos, S Faiss, R Tauber, B Wiedenmann, and R Gessner LI-cadherin: a marker of gastric metaplasia and neoplasia Gut, July 1, 2001; 49(1): 73 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A O O Chan, S K Lam, K M Chu, C M Lam, E Kwok, S Y Leung, S T Yuen, S Y K Law, W M Hui, K C Lai, et al. Soluble E-cadherin is a valid prognostic marker in gastric carcinoma Gut, June 1, 2001; 48(6): 808 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Slaton, K. Inoue, P. Perrotte, A. K. El-Naggar, D. A. Swanson, I. J. Fidler, and C. P. N. Dinney Expression Levels of Genes that Regulate Metastasis and Angiogenesis Correlate with Advanced Pathological Stage of Renal Cell Carcinoma Am. J. Pathol., February 1, 2001; 158(2): 735 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Thomas and P.M. Speight Cell Adhesion Molecules and Oral Cancer Critical Reviews in Oral Biology & Medicine, January 1, 2001; 12(6): 479 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Herbst, S. Yano, H. Kuniyasu, F. R. Khuri, C. D. Bucana, F. Guo, D. Liu, B. Kemp, J. J. Lee, W. K. Hong, et al. Differential Expression of E-cadherin and Type IV Collagenase Genes Predicts Outcome in Patients with Stage I Non-Small Cell Lung Carcinoma Clin. Cancer Res., March 1, 2000; 6(3): 790 - 797. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. W. Owens, G. W. McLean, A. W. Wyke, C. Paraskeva, E. K. Parkinson, M. C. Frame, and V. G. Brunton The Catalytic Activity of the Src Family Kinases Is Required to Disrupt Cadherin-dependent Cell-Cell Contacts Mol. Biol. Cell, January 1, 2000; 11(1): 51 - 64. [Abstract] [Full Text]
|
|
|
|
|
|
K.-F. Becker, E. Kremmer, M. Eulitz, I. Becker, G. Handschuh, C. Schuhmacher, W. Muller, H. E. Gabbert, A. Ochiai, S. Hirohashi, et al. Analysis of E-Cadherin in Diffuse-Type Gastric Cancer Using a Mutation-Specific Monoclonal Antibody Am. J. Pathol., December 1, 1999; 155(6): 1803 - 1809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kuniyasu, L. M. Ellis, D. B. Evans, J. L. Abbruzzese, C. J. Fenoglio, C. D. Bucana, K. R. Cleary, E. Tahara, and I. J. Fidler Relative Expression of E-Cadherin and Type IV Collagenase Genes Predicts Disease Outcome in Patients with Resectable Pancreatic Carcinoma Clin. Cancer Res., January 1, 1999; 5(1): 25 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hirohashi Inactivation of the E-Cadherin-Mediated Cell Adhesion System in Human Cancers Am. J. Pathol., August 1, 1998; 153(2): 333 - 339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Machado, F. Carneiro, S. Beck, S. Rossi, J. Lopes, A. Taveira-Gomes, and M. Cardoso-Oliveira E-Cadherin Expression Is Correlated with the Isolated Cell/Diffuse Histotype and with Features of Biological Aggressiveness of Gastric Carcinoma International Journal of Surgical Pathology, July 1, 1998; 6(3): 135 - 144. [Abstract] [PDF]
|
|
|
|
|
|
S. Norvell and K. Green Contributions of extracellular and intracellular domains of full length and chimeric cadherin molecules to junction assembly in epithelial cells J. Cell Sci., January 5, 1998; 111(9): 1305 - 1318. [Abstract] [PDF]
|
|
|
|
 |
|
 E. M. Fish and B. A. Molitoris Alterations in Epithelial Polarity and the Pathogenesis of Disease States N. Engl. J. Med., June 2, 1994; 330(22): 1580 - 1588. [Full Text]
|
|
|
|
|
|
A Tang, M. Eller, M Hara, M Yaar, S Hirohashi, and B. Gilchrest E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro J. Cell Sci., January 4, 1994; 107(4): 983 - 992. [Abstract] [PDF]
|
|
|
|
|
|
P Navarro, E Lozano, and A Cano Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin J. Cell Sci., January 8, 1993; 105(4): 923 - 934. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Takeichi, S. Hirano, N. Matsuyoshi, and T. Fujimori Cytoplasmic Control of Cadherin-mediated Cell-Cell Adhesion Cold Spring Harb Symp Quant Biol, January 1, 1992; 57(0): 327 - 334. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
