This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wu-Williams, A. H. Articles by Henderson, B. E. Search for Related Content PubMed PubMed Citation Articles by Wu-Williams, A. H. Articles by Henderson, B. E.

Reproductive Factors and Colorectal Cancer Risk among Chinese Females¹

Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles, California 90033-9987 [A. H. W-W., B. E. H.]; University of California, San Francisco, California 94143 [M. L.]; Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California 94305 [A. S. W., D. J., R. S. P.]; Division of Epidemiology and Biometry and Occupational Oncology, British Columbia Cancer Agency, Vancouver, British Columbia V5Z4E6, Canada [R. P. G., C-Z. T.]; and Zhejiang Medical University, Hangzhou, People's Republic of China [J. D., Z. S., Z. L., W. X., C. K., L. C., X. J. Y.]

We report results from a population-based case-control study of colorectal cancer among Chinese women in western North America (NA) and the People's Republic of China (China). A common protocol was used to assess reproductive characteristics and hormone use of 395 Chinese women (189 from NA and 206 from China) with cancer of the colon or rectum and of 1112 age-matched Chinese controls (494 from NA and 618 from China). In NA, risks for cancers of both the colon and rectum were lower among parous compared to nulliparous women (odds ratio for colorectal cancer, 0.6, P = 0.08), but the trend in risk was not smooth with increasing number of livebirths. This association with parity was absent for both cancer sites in China. There were no consistent patterns in the relationships between other reproductive factors (including age at menarche, age at first livebirth, menopausal status) and risk of colon and rectal cancer on either continent.

¹ Supported by Public Health Service Grants CA-36503 and CA-44854 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services; by Health and Welfare Canada Grant 6610-1472-53; by British Columbia Health Care Research Foundation Grant 112 (84-1); and by the National Academy of Sciences of the People's Republic of China.

² To whom requests for reprints should be addressed, at Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033.

Received 9/24/90. Accepted 2/22/91.

This article has been cited by other articles:

				J. Lin, S. M. Zhang, N. R. Cook, J. E. Manson, J. E. Buring, and I-M. Lee Oral Contraceptives, Reproductive Factors, and Risk of Colorectal Cancer among Women in a Prospective Cohort Study Am. J. Epidemiol., April 1, 2007; 165(7): 794 - 801. [Abstract] [Full Text] [PDF]

				H. B. Nichols, A. Trentham-Dietz, J. M. Hampton, and P. A. Newcomb Oral Contraceptive Use, Reproductive Factors, and Colorectal Cancer Risk: Findings from Wisconsin Cancer Epidemiol. Biomarkers Prev., May 1, 2005; 14(5): 1212 - 1218. [Abstract] [Full Text] [PDF]

				J. D. Potter Colorectal Cancer: Molecules and Populations J Natl Cancer Inst, June 2, 1999; 91(11): 916 - 932. [Abstract] [Full Text] [PDF]

				K. Nanda, L. A. Bastian, V. Hasselblad, and D. L. Simel HORMONE REPLACEMENT THERAPY AND THE RISK OF COLORECTAL CANCER: A META-ANALYSIS Obstet. Gynecol., May 1, 1999; 93(5): 880 - 888. [Abstract] [Full Text] [PDF]