| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Division of Oncology, Department of Microbiology, Shionogi Research Laboratories, Shionogi & Co., Ltd., 4–12, 5-chome, Sagisu, Fukushima-ku, Osaka 553, Japan
Trichostatin A (TSA) induced the normal and flat phenotype of sis-transformed NIH3T3 cells at quite a low concentration of 1 ng/ml. Although morphological changes were found in other oncogene-transformed cells, they were not the same as those seen for the sis-transformed cells. Almost complete reversion into the flat phenotype was seen at 6 h after administration of the compound, suggesting that the morphological change was caused not merely by selection of TSA-resistant cells of the flat phenotype. The effect of TSA was reversible when the cell culture was incubated after its removal. Synthesis of sis-mRNA did not decrease with the treatment of TSA at a concentration sufficient to reverse the transformed morphology. Cycloheximide abolished the activity of TSA, showing that TSA required new protein synthesis to express its activity.
1 To whom requests for reprints should be addressed.
Received 7/30/91. Accepted 10/16/91.
This article has been cited by other articles:
|
|
 |
|
  X. D. Zhang, S. K. Gillespie, J. M. Borrow, and P. Hersey The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells Mol. Cancer Ther., April 1, 2004; 3(4): 425 - 435. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T.-H. Leu, H. H. Yeh, C.-C. Huang, Y.-C. Chuang, S. L. Su, and M.-C. Maa Participation of p97Eps8 in Src-mediated Transformation J. Biol. Chem., March 12, 2004; 279(11): 9875 - 9881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Antos, T. A. McKinsey, M. Dreitz, L. M. Hollingsworth, C.-L. Zhang, K. Schreiber, H. Rindt, R. J. Gorczynski, and E. N. Olson Dose-dependent Blockade to Cardiomyocyte Hypertrophy by Histone Deacetylase Inhibitors J. Biol. Chem., August 1, 2003; 278(31): 28930 - 28937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ju and M. T. Muller Histone Deacetylase Inhibitors Activate p21WAF1 Expression via ATM Cancer Res., June 1, 2003; 63(11): 2891 - 2897. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Weston, R. A.S. Chandraratna, J. Torchia, and T. M. Underhill Requirement for RAR-mediated gene repression in skeletal progenitor differentiation J. Cell Biol., July 8, 2002; 158(1): 39 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Lim, I. Han, H. J. Kwon, and E.-S. Oh Trichostatin A-induced Detransformation Correlates with Decreased Focal Adhesion Kinase Phosphorylation at Tyrosine 861 in ras-transformed Fibroblasts J. Biol. Chem., April 5, 2002; 277(15): 12735 - 12740. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Duharcourt and M.-C. Yao Role of Histone Deacetylation in Developmentally Programmed DNA Rearrangements in Tetrahymena thermophila Eukaryot. Cell, April 1, 2002; 1(2): 293 - 303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Sambucetti, D. D. Fischer, S. Zabludoff, P. O. Kwon, H. Chamberlin, N. Trogani, H. Xu, and D. Cohen Histone Deacetylase Inhibition Selectively Alters the Activity and Expression of Cell Cycle Proteins Leading to Specific Chromatin Acetylation and Antiproliferative Effects J. Biol. Chem., December 3, 1999; 274(49): 34940 - 34947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sowa, T. Orita, S. Minamikawa-Hiranabe, T. Mizuno, H. Nomura, and T. Sakai Sp3, but not Sp1, Mediates the Transcriptional Activation of the p21/WAF1/Cip1 Gene Promoter by Histone Deacetylase Inhibitor Cancer Res., September 1, 1999; 59(17): 4266 - 4270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Kwon, T. Owa, C. A. Hassig, J. Shimada, and S. L. Schreiber Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase PNAS, March 31, 1998; 95(7): 3356 - 3361. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
