Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention AACR Conference on Molecular Diagnostics - 2008
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 52, 3224-3227, June 1, 1992]
© 1992 American Association for Cancer Research
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cook, P. W.
Right arrow Articles by Shipley, G. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cook, P. W.
Right arrow Articles by Shipley, G. D.

Amphiregulin Messenger RNA Is Elevated in Psoriatic Epidermis and Gastrointestinal Carcinomas1

Paul W. Cook, Mark R. Pittelkow, Winifred W. Keeble, Ramona Graves-Deal, Robert J. Coffey, Jr. and Gary D. Shipley2

Department of Cell Biology and Anatomy, Oregon Health Sciences University, Portland, Oregon 97201 [P. W. C., W. W. K., G. D. S.]; Department of Dermatology, Mayo Clinic/Foundation, Rochester, Minnesota 55905 [M. R. P.]; and Departments of Cell Biology and Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 [R. J. C., R. G-D.]

Amphiregulin (AR) is a heparin-regulated, epidermal growth factor-like growth factor capable of stimulating the proliferation of non-tumorigenic cells while inhibiting cell proliferation in some human tumor cell lines in vitro. In the present study, we have investigated AR mRNA expression in normal, hyperproliferative, and neoplastic human epithelium. Our results demonstrate that, compared with the adjacent uninvolved epithelium, AR mRNA expression is markedly elevated in epidermal biopsies derived from three human psoriatic lesions as well as in biopsies derived from five human colon carcinomas and three human stomach carcinomas. Moreover, analysis of a colon carcinoma by in situ hybridization revealed that AR mRNA is localized to the epithelium.

1 This work was supported by NIH Grants CA42409 (G. D. S.), CA 46413 (R. J. C.), and AR39547 (M. R. P.); a grant from Clonetics Corporation (G. D. S.); a grant from the Veterans Administration (R. J. C.); and a grant from the Mayo Foundation (M. R. P.).

2 To whom requests for reprints should be addressed, at OHSU-L215, 3181 S.W. Sam Jackson Park Road, Portland, OR 97201.

Received 1/29/92. Accepted 4/16/92.




This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
M. R. Schneider, S. Werner, R. Paus, and E. Wolf
Beyond Wavy Hairs: The Epidermal Growth Factor Receptor and Its Ligands in Skin Biology and Pathology
Am. J. Pathol., July 1, 2008; 173(1): 14 - 24.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
N. Bhagavathula, K. C. Nerusu, A. Hanosh, M. N. Aslam, T. B. Sundberg, A. W. Opipari Jr., K. Johnson, S. Kang, G. D. Glick, and J. Varani
7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(naphthalen-2-ylmethyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one (Bz-423), a Benzodiazepine, Suppresses Keratinocyte Proliferation and Has Antipsoriatic Activity in the Human Skin-Severe, Combined Immunodeficient Mouse Transplant Model
J. Pharmacol. Exp. Ther., March 1, 2008; 324(3): 938 - 947.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. B. Merchant, I. Voskresensky, C. M. Rogers, B. LaFleur, P. J. Dempsey, R. Graves-Deal, F. Revetta, A. C. Foutch, M. L. Rothenberg, M. K. Washington, et al.
TACE/ADAM-17: A Component of the Epidermal Growth Factor Receptor Axis and a Promising Therapeutic Target in Colorectal Cancer
Clin. Cancer Res., February 15, 2008; 14(4): 1182 - 1191.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
N. Bhagavathula, K. C. Nerusu, M. Reddy, C. N. Ellis, A. Chittiboyina, M. Avery, H. A. Pershadsingh, T. W. Kurtz, and J. Varani
BP-1107 [{2-[4-(2,4-Dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-methyl-amide]: A Novel Synthetic Thiazolidinedione That Inhibits Epidermal Hyperplasia in Psoriatic Skin-Severe-Combined Immunodeficient Mouse Transplants after Topical Application
J. Pharmacol. Exp. Ther., December 1, 2005; 315(3): 996 - 1004.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Tokumaru, K. Sayama, Y. Shirakata, H. Komatsuzawa, K. Ouhara, Y. Hanakawa, Y. Yahata, X. Dai, M. Tohyama, H. Nagai, et al.
Induction of Keratinocyte Migration via Transactivation of the Epidermal Growth Factor Receptor by the Antimicrobial Peptide LL-37
J. Immunol., October 1, 2005; 175(7): 4662 - 4668.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J. Varani, N. Bhagavathula, K. C. Nerusu, H. Sherzer, K. Fay, A. E. Boitano, G. D. Glick, K. Johnson, S. Kang, and A. W. Opipari Jr.
A Novel Benzodiazepine Selectively Inhibits Keratinocyte Proliferation and Reduces Retinoid-Induced Epidermal Hyperplasia in Organ-Cultured Human Skin
J. Pharmacol. Exp. Ther., April 1, 2005; 313(1): 56 - 63.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
N. Bhagavathula, K. C. Nerusu, G. J. Fisher, G. Liu, A. B. Thakur, L. Gemmell, S. Kumar, Z. H. Xu, P. Hinton, N. Tsurushita, et al.
Amphiregulin and Epidermal Hyperplasia: Amphiregulin Is Required to Maintain the Psoriatic Phenotype of Human Skin Grafts on Severe Combined Immunodeficient Mice
Am. J. Pathol., April 1, 2005; 166(4): 1009 - 1016.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. C. Johansson, A. Yndestad, J. M. Enserink, A. H. Ree, P. Aukrust, and K. Tasken
The Epidermal Growth Factor-Like Growth Factor Amphiregulin Is Strongly Induced by the Adenosine 3',5'-Monophosphate Pathway in Various Cell Types
Endocrinology, November 1, 2004; 145(11): 5177 - 5184.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
S. Kansra, S. W. Stoll, J. L. Johnson, and J. T. Elder
Autocrine Extracellular Signal-regulated Kinase (ERK) Activation in Normal Human Keratinocytes: Metalloproteinase-mediated Release of Amphiregulin Triggers Signaling from ErbB1 to ERK
Mol. Biol. Cell, September 1, 2004; 15(9): 4299 - 4309.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. D. Billings, M. D. Southall, T. Li, P. W. Cook, L. Baldridge, W. B. Moores, D. F. Spandau, J. G. Foley, and J. B. Travers
Amphiregulin Overexpression Results in Rapidly Growing Keratinocytic Tumors: An In Vivo Xenograft Model of Keratoacanthoma
Am. J. Pathol., December 1, 2003; 163(6): 2451 - 2458.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
S. W. Stoll, S. Kansra, and J. T. Elder
Metalloproteinases Stimulate ErbB-dependent ERK Signaling in Human Skin Organ Culture
J. Biol. Chem., July 19, 2002; 277(30): 26839 - 26845.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. M. Cox, C. L. Clayton, T. Tomita, D. M. Wallace, P. A. Robinson, and J. E. Crabtree
cDNA Array Analysis of cag Pathogenicity Island-Associated Helicobacter pylori Epithelial Cell Response Genes
Infect. Immun., November 1, 2001; 69(11): 6970 - 6980.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
M. Jost, T. M. Huggett, C. Kari, and U. Rodeck
Matrix-independent Survival of Human Keratinocytes through an EGF Receptor/MAPK-Kinase-dependent Pathway
Mol. Biol. Cell, May 1, 2001; 12(5): 1519 - 1527.
[Abstract] [Full Text]

Home page
 MutagenesisHome page
L. Bassi, R. Buzzi, M. Fiore, and F. Palitti
Clastogenic effects of two tyrosine kinase inhibitors, Tyrphostin 23 and Tyrphostin 46, on a transformed (CHO-K1) and on a primary embryonic Chinese hamster cell line (CHE)
Mutagenesis, July 1, 2000; 15(4): 341 - 347.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
S. K. Kuwada and X. Li
Integrin alpha 5/beta 1 Mediates Fibronectin-dependent Epithelial Cell Proliferation through Epidermal Growth Factor Receptor Activation
Mol. Biol. Cell, July 1, 2000; 11(7): 2485 - 2496.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
Y. Shirakata, T. Komurasaki, H. Toyoda, Y. Hanakawa, K. Yamasaki, S. Tokumaru, K. Sayama, and K. Hashimoto
Epiregulin, a Novel Member of the Epidermal Growth Factor Family, Is an Autocrine Growth Factor in Normal Human Keratinocytes
J. Biol. Chem., February 25, 2000; 275(8): 5748 - 5753.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Wong, T. B. Deb, S. A. Thompson, A. Wells, and G. R. Johnson
A Differential Requirement for the COOH-terminal Region of the Epidermal Growth Factor (EGF) Receptor in Amphiregulin and EGF Mitogenic Signaling
J. Biol. Chem., March 26, 1999; 274(13): 8900 - 8909.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. L. Brown, K. S. Meise, G. D. Plowman, R. J. Coffey, and P. J. Dempsey
Cell Surface Ectodomain Cleavage of Human Amphiregulin Precursor Is Sensitive to a Metalloprotease Inhibitor. RELEASE OF A PREDOMINANT N-GLYCOSYLATED 43-kDa SOLUBLE FORM
J. Biol. Chem., July 3, 1998; 273(27): 17258 - 17268.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
U. Rodeck, M. Jost, J. DuHadaway, C. Kari, P. J. Jensen, B. Risse, and D. L. Ewert
Regulation of Bcl-xL expression in human keratinocytes by cell-substratum adhesion and the epidermal growth factor receptor
PNAS, May 13, 1997; 94(10): 5067 - 5072.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Parrizas, A. Gazit, A. Levitzki, E. Wertheimer, and D. LeRoith
Specific Inhibition of Insulin-Like Growth Factor-1 and Insulin Receptor Tyrosine Kinase Activity and Biological Function by Tyrphostins
Endocrinology, April 1, 1997; 138(4): 1427 - 1433.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. J. Coffey, C. J. Hawkey, L. Damstrup, R. Graves-Deal, V. C. Daniel, P. J. Dempsey, R. Chinery, S. C. Kirkland, R. N. DuBois, T. L. Jetton, et al.
Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells
PNAS, January 21, 1997; 94(2): 657 - 662.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. A. Thompson, A. Harris, D. Hoang, M. Ferrer, and G. R. Johnson
COOH-terminal Extended Recombinant Amphiregulin with Bioactivity Comparable with Naturally Derived Growth Factor
J. Biol. Chem., July 26, 1996; 271(30): 17927 - 17931.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
A Levitzki and A Gazit
Tyrosine kinase inhibition: an approach to drug development
Science, March 24, 1995; 267(5205): 1782 - 1788.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1992 by the American Association for Cancer Research.