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SAS Amplification in Soft Tissue Sarcomas¹

Departments of Pediatrics [S. H. S., P. S. M.], Pathology [S. W. W.], Human Genetics [S. A. J.], and Radiation Oncology [P. S. M.], University of Michigan Medical Center, Ann Arbor, Michigan 48109, and the Department of Microbiology, University of Arizona, Tucson, Arizona 85724 [M. A. C.]

Gene amplification is an important mechanism of increased gene expression in a number of human solid tumors. We have recently identified and cloned sequences from a novel DNA amplification unit in malignant fibrous histiocytoma. The amplified sequences are derived from chromosome 12q13-14 and encode a gene designated SAS (sarcoma amplified sequence). In the present study, a series of soft tissue sarcomas was studied to characterize further the phenomenon of SAS amplification. Seven of 22 (32%) malignant fibrous histiocytomas and three liposarcomas contained SAS amplification. Strikingly, all of the tumors with SAS amplification occurred in central sites (i.e., in the abdominal or inguinal regions) rather than in the extremities (i.e., in the arms or legs). These observations demonstrate that SAS amplification occurs with a significant frequency in mesenchymal tumors and is particularly associated with abdominal disease.

¹ This work was supported by a grant (CA-56725) from the National Cancer Institute.

² To whom requests for reprints should be addressed.

Received 2/20/92. Accepted 4/22/92.

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