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Department of Surgery II, Kumamoto University Medical School, Honjo 1-1-1, Kumamoto 860 [J. Y., M. O., H. E., S. M., H. K., K. I., S-i. Y.], and Kitazato Biochemical Laboratories, Kitazato 1-15-1, Sagamihara, Kanagawa 228 [S. F.], Japan
Immunoreactive endothelin 1 (irET-1) concentrations were measured in extracts prepared from 4 phyllodes tumors and 14 fibroadenomas. irET-1 was detectable in all tissue extracts by specific radioimmunoassay, and the mean concentration of irET-1 was 18-fold and 27-fold higher in tissue extracts from phyllodes tumors than in those from intracanalicular fibroadenomas and pericanalicular fibroadenomas, respectively. Reverse-phase high-performance liquid chromatography coupled with radioimmunoassay in the extracts from phyllodes tumors revealed one major irET-1 component corresponding to human standard ET-1. Furthermore, immunocytochemical staining for ET-1 revealed that numerous ET-1-immunoreactive cells were seen in the epithelial cells but not in the stromal cells, suggesting that ET-1 is synthesized by the epithelial component of phyllodes tumors. A possible paracrine role of ET-1 in the growth of this rare tumor which is characterized by its prominent stromal cellularity is discussed.
1 To whom requests for reprints should be addressed.
Received 5/12/92. Accepted 6/ 1/92.
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