This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lattime, E. C. Articles by McCue, P. A. Search for Related Content PubMed PubMed Citation Articles by Lattime, E. C. Articles by McCue, P. A.

Murine Bladder Carcinoma Cells Present Antigen to BCG-specific CD4⁺ T-Cells¹

Division of Medical Oncology, Department of Medicine [E. C. L.]; and Departments of Urology [L. G. G.], and Pathology [P. A. M.], Thomas Jefferson University, Philadelphia, Pennsylvania 19107

Intravesical administration of Bacillus Calmette-Guérin (BCG) is the most effective therapy for superficial transitional cell carcinoma of the bladder although its mechanism of action is not known. To determine if bladder tumors are capable of antigen presentation and thus might interact directly with BCG-specific T-cells, we studied the murine bladder tumor MB49. MB49 (MHC Class II negative) (IA^-), when induced to express IA with interferon, presented BCG to specific CD4⁺ T-cells obtained from bladder-draining lymph nodes following intravesical BCG administration. This interaction resulted in antigen- and IA-dependent interleukin 2 and tumor necrosis factor production. Interferon also induced MB49 IA expression in vivo. This first demonstration of antigen presentation by epithelial tumors supports new approaches to immunotherapy of these malignancies.

¹ Supported by USPHS Grant CA-42908.

² To whom requests for reprints should be addressed, at Thomas Jefferson University, Division of Medical Oncology, 7015 Walnut St. Suite 1005, Philadelphia, PA 19107.

Received 3/30/92. Accepted 6/15/92.

This article has been cited by other articles:

				J-P Meyer, R Persad, and D A Gillatt Use of bacille Calmette-Guerin in superficial bladder cancer Postgrad. Med. J., August 1, 2002; 78(922): 449 - 454. [Abstract] [Full Text] [PDF]

				J. P. Lavelle, G. Apodaca, S. A. Meyers, W. G. Ruiz, and M. L. Zeidel Disruption of guinea pig urinary bladder permeability barrier in noninfectious cystitis Am J Physiol Renal Physiol, January 1, 1998; 274(1): F205 - F214. [Abstract] [Full Text] [PDF]