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Human T-Cell Leukemia Virus Type I or a Related Retrovirus in Patients with Mycosis Fungoides/Sézary Syndrome and Kaposi's Sacroma¹

Departments of Molecular Medicine and Immunology and of Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263

Antibodies reactive with human T-cell leukemia virus type I (HTLV-I) proteins p19, p24, gp46, p56, and gp68 were detected in four of 27 patients with mycosis fungoides/Sézary syndrome (MF/SS) and one patient with Kaposi's sarcoma using radioimmunoprecipitation and Western blot analysis. Seroreactivity patterns to HTLV-I proteins of MF/SS sera were indeterminate or limited in comparison with sera of patients with adult T-cell leukemia/lymphoma. HTLV-I gag- and tax/rex-specific DNA was demonstrated in peripheral blood from three of the MF/SS patients and from the patient with Kaposi's sarcoma by the polymerase chain reaction. HTLV-I-specific DNA sequences were not detected in a cohort of seven seronegative MF/SS patients. The frequency of HTLV-I infection was four of 27 or 14.8% among the MF/SS patients, which is several hundredfold higher than in normal blood donors. The present data suggest a possible association of HTLV-I or a related retrovirus with mycosis fungoides/Sézary syndrome and Kaposi's sarcoma.

¹ This work was supported in part by Grant SO7 RR-05648-23 from the Biomedical Research Support Grant Program, Division of Research Resources, NIH; Institutional Research Grant IN-54-30 of the American Cancer Society; the Association of Research of Childhood Cancer; and a grant from the Pardee Cancer Research Foundation.

² To whom requests for reprints should be addressed, at Department of Medicine, State University of New York, Health Science Center, Syracuse, NY 13210.

Received 11/11/91. Accepted 6/ 4/92.

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