This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Surmacz, E. Articles by Baserga, R. Search for Related Content PubMed PubMed Citation Articles by Surmacz, E. Articles by Baserga, R.

Cyclin D1 Messenger RNA Is Inducible by Platelet-derived Growth Factor in Cultured Fibroblasts¹

Jefferson Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5541

In fibrobiasts in culture, the levels of cyclin D1 mRNA are growth regulated. In mouse and in human fibroblasts, both serum and platelet-derived growth factor increase cyclin D1 mRNA levels with similar kinetics of induction. Insulin-like growth factor 1 by itself does not induce cyclin D1 expression, and an antisense oligodeoxynucleotide to the insulin-like growth factor 1 receptor RNA does not affect the growth-regulated levels of cyclin D1 mRNA.

¹ This work was supported by Grants GM 33694 and CA53484 from the NIH.

Received 3/24/92. Accepted 6/ 5/92.

This article has been cited by other articles:

				J. Chen, A. Wu, H. Sun, R. Drakas, C. Garofalo, S. Cascio, E. Surmacz, and R. Baserga Functional Significance of Type 1 Insulin-like Growth Factor-mediated Nuclear Translocation of the Insulin Receptor Substrate-1 and {beta}-Catenin J. Biol. Chem., August 19, 2005; 280(33): 29912 - 29920. [Abstract] [Full Text] [PDF]

				S. LANG, A. HARTNER, R. B. STERZEL, and H. O. SCHÖCKLMANN Requirement of Cyclin D1 in Mesangial Cell Mitogenesis J. Am. Soc. Nephrol., August 1, 2000; 11(8): 1398 - 1408. [Abstract] [Full Text]

				Y.-X. Yan, H. Nakagawa, M.-H. Lee, and A. K. Rustgi Transforming Growth Factor-alpha Enhances Cyclin D1 Transcription through the Binding of Early Growth Response Protein to a cis-Regulatory Element in the Cyclin D1 Promoter J. Biol. Chem., December 26, 1997; 272(52): 33181 - 33190. [Abstract] [Full Text] [PDF]

				H. Koyama, Y. Nishizawa, M. Hosoi, S. Fukumoto, K. Kogawa, A. Shioi, and H. Morii The Fumagillin Analogue TNP-470 Inhibits DNA Synthesis of Vascular Smooth Muscle Cells Stimulated by Platelet-Derived Growth Factor and Insulin-like Growth Factor-I: Possible Involvement of Cyclin-Dependent Kinase 2 Circ. Res., October 1, 1996; 79(4): 757 - 764. [Abstract] [Full Text]

				W. Cheng, K. Reiss, P. Li, M. J. Chun, J. Kajstura, G. Olivetti, and P. Anversa Aging Does Not Affect the Activation of the Myocyte Insulin-Like Growth Factor-1 Autocrine System After Infarction and Ventricular Failure in Fischer 344 Rats Circ. Res., April 1, 1996; 78(4): 536 - 546. [Abstract] [Full Text]