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Amplification of Genes within the Chromosome 11q13 Region Is Indicative of Poor Prognosis in Patients with Operable Breast Cancer¹

Divisions of Tumor Biology and Pathology [E. S., E. V., J. L. P., B. N., W. J. M., R. J. A. M. M.] and Department of Biometrics [H. v. T.], The Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis), Plesmanlaan 121, 1066 CX, Amsterdam; Department of Pathology, Academic Hospital Maastricht, 6202 AZ, Maastricht [F. B. J. M. T.]; and Laboratory of Pathology, University of Leiden, 2300 RC, Leiden [P. D., C. J. C., M. J. v. d. V.], The Netherlands

Amplification of the chromosome 11q13 region, which harbors the BCL1 region and the PRAD1, EMS1, HSTF1, and INT2 genes, was found in 36 (16%) of a series of 226 breast carcinomas. In the 153 patients with stage I–IIIa disease who had received no therapy prior to surgery and who were treated with curative intent, 11q13 amplification was associated with the presence of lymph node metastases (P < 0.002). The presence of an 11q13 amplification was associated with a significantly shorter relapse-free survival (P < 0.002) and a higher breast cancer-specific mortality (P < 0.003). Stepwise multivariate analysis showed that, in addition to lymph node status, 11q13 amplification was the best predictor for short survival. Stratified log-rank analysis indicated that, within the group of lymph node-positive breast cancer patients, 11q13 amplification identifies a subgroup at high risk.

¹ This study was supported by Grant NKB 87-12 from the Dutch Cancer Society.

² To whom requests for reprints should be addressed, at the Laboratory of Pathology, University of Leiden, P.O. Box 9603, NL-2300 RC, Leiden, The Netherlands.

Received 2/28/92. Accepted 7/17/92.

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