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A Measure of Genomic Instability and Its Relevance to Lymphomagenesis¹

National Cancer Institute-Navy Medical Oncology Branch, Bethesda, Maryland 20889-5105

A recent pilot study that we performed on 12 individuals who are involved in the cultivation and processing of grains and legumes suggests to us that we may have in hand a relatively quick, inexpensive, and highly sensitive assay that identifies individuals at increased risk for the development of lymphoid malignancy. The generation of this assay evolved from our interest in the causes and consequences of lymphocyte-specific chromosomal aberration.