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Glycosphingolipids of Various Human Ovarian Tumors: A Significantly High Expression of I³SO₃GalCer and Lewis Antigen in Mucinous Cystadenocarcinoma

Department of Obstetrics and Gynecology, Keio University School of Medicine, 35, Shinano-machi, Shinjuku-ku [K. K., K. T., J. T., S. N.], Department of Biochemistry, Faculty of Medicine, University of Tokyo, Bunkyo-ku [M. I.], and Tokyo Metropolitan Institute of Medical Science, Komagome, Bunkyo-ku [Y. N.], Tokyo, Japan

Among several human ovarian tumors, which include mucinous cystadenocarcinoma, serous cystadenocarcinoma, and clear cell adenocarcinoma, the mucinous cystadenocarcinoma showed a unique glycosphingolipid composition. In particular, more than 90% of the acidic glycosphingolipids in the mucinous cystadenocarcinoma is comprised of sulfolipids, which are hardly detected in normal ovary and are contained in concentrations of less than 40% in the other type of ovarian tumors. By means of negative ion fast atom bombardment mass spectrometry and gas liquid chromatography, the major sulfolipid in mucinous cystadenocarcinoma is confirmed to be I³SO₃-GalCer with N-cerebronoyl phytosphingosine, that which contrasts with I³SO₃-GalCer with N-nonhydroxy fatty acyl sphingosine as the major molecular species in the other ovarian cancers. In mucinous cystadenocarcinoma, galactosylceramide is found in the relatively high concentration and is also composed of N-cerebronoyl phytosphingosine. In addition, the concentrations of glycolipids with Le^a and Le^b antigenicities are significantly higher in mucinous cystadenocarcinoma than those in normal ovary and the other ovarian tumors.

¹ To whom requests for reprints should be addressed.

Received 8/19/91. Accepted 10/31/91.

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