This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kiguchi, K. Articles by Nagai, Y. Search for Related Content PubMed PubMed Citation Articles by Kiguchi, K. Articles by Nagai, Y.

Glycosphingolipids of Various Human Ovarian Tumors: A Significantly High Expression of I³SO₃GalCer and Lewis Antigen in Mucinous Cystadenocarcinoma

Department of Obstetrics and Gynecology, Keio University School of Medicine, 35, Shinano-machi, Shinjuku-ku [K. K., K. T., J. T., S. N.], Department of Biochemistry, Faculty of Medicine, University of Tokyo, Bunkyo-ku [M. I.], and Tokyo Metropolitan Institute of Medical Science, Komagome, Bunkyo-ku [Y. N.], Tokyo, Japan

Among several human ovarian tumors, which include mucinous cystadenocarcinoma, serous cystadenocarcinoma, and clear cell adenocarcinoma, the mucinous cystadenocarcinoma showed a unique glycosphingolipid composition. In particular, more than 90% of the acidic glycosphingolipids in the mucinous cystadenocarcinoma is comprised of sulfolipids, which are hardly detected in normal ovary and are contained in concentrations of less than 40% in the other type of ovarian tumors. By means of negative ion fast atom bombardment mass spectrometry and gas liquid chromatography, the major sulfolipid in mucinous cystadenocarcinoma is confirmed to be I³SO₃-GalCer with N-cerebronoyl phytosphingosine, that which contrasts with I³SO₃-GalCer with N-nonhydroxy fatty acyl sphingosine as the major molecular species in the other ovarian cancers. In mucinous cystadenocarcinoma, galactosylceramide is found in the relatively high concentration and is also composed of N-cerebronoyl phytosphingosine. In addition, the concentrations of glycolipids with Le^a and Le^b antigenicities are significantly higher in mucinous cystadenocarcinoma than those in normal ovary and the other ovarian tumors.

¹ To whom requests for reprints should be addressed.

Received 8/19/91. Accepted 10/31/91.

This article has been cited by other articles:

				N. L. Alderson and H. Hama Fatty acid 2-hydroxylase regulates cAMP-induced cell cycle exit in D6P2T Schwannoma cells J. Lipid Res., June 1, 2009; 50(6): 1203 - 1208. [Abstract] [Full Text] [PDF]

				J. Garcia, N. Callewaert, and L. Borsig P-selectin mediates metastatic progression through binding to sulfatides on tumor cells Glycobiology, February 1, 2007; 17(2): 185 - 196. [Abstract] [Full Text] [PDF]

				M. Kyogashima, K. Tamiya-Koizumi, T. Ehara, G. Li, R. Hu, A. Hara, T. Aoyama, and R. Kannagi Rapid demonstration of diversity of sulfatide molecular species from biological materials by MALDI-TOF MS Glycobiology, August 1, 2006; 16(8): 719 - 728. [Abstract] [Full Text] [PDF]