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Divisions of Experimental Oncology A [G. S., M. M., R. D., C. T. C., G. D. P., M. A. P.], Anatomical Pathology and Cytology [S. P.], and Chest Surgery [U. P.], Istituto Nazionale Tumori, Via G. Venezian 1, 20133 Milano, Italy
Cytogenetic and p53 mutation analysis in two cases of severe dysplasia of the bronchial epithelium in lung cancer patients and p53 immunostaining in a third one are reported. The finding of both chromosomal deletions of 17p and p53 mutation indicates that these changes may take place early in the process of lung carcinogenesis.
1 This work was supported by the Italian Association for Cancer Research, Ministero della Sanità, Rome, and by the Italian National Research Council (Special Project: Applicazioni Cliniche della Ricerca Oncologica).
2 To whom requests for reprints should be addressed.
Received 7/ 3/92. Accepted 8/25/92.
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