| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Urological Research Laboratory [A. P. M. V., T. W. A., F. M. J. D., J. A. S.] and Department of Pathology [H. E. S.], University Hospital Nijmegen, Nijmegen, the Netherlands, and Department of Molecular Cell Biology and Genetics, University of Limburg, Maastricht, the Netherlands [F. C. S. R.]
In the epithelium of secretory acini of the prostate two different cell types can be discriminated on the basis of localization, morphology, and degree of differentiation, the luminal and basal cells. The possibility of a developmental relationship between basal and luminal cells has been a subject of interest in several studies. According to the stem cell model at least three cell types, i.e., stem, amplifying, and transit cells, can be discriminated in the epithelium of prostate secretory acini. We previously reported that in the process of degeneration and regeneration in normal rat prostate a population of cells could be identified as candidates for the amplifying cells. These cells showed a keratin expression profile intermediate between those of basal and luminal cells. We now show, by using keratin antibodies, that also in normal human prostate at least three subpopulations of cells can be identified, one of them putatively representing amplifying cells as defined in the stem cell model. Furthermore, these antibodies were used to obtain a better insight into the different cell types involved in the etiology and progression of prostatic carcinoma. Both primary and hormone-independent prostatic tumors were investigated. Our results indicated that the candidate stem cell population was absent in prostatic carcinoma. Unlike earlier reports on the unique presence of cells with luminal characteristics in prostatic carcinoma, we identified also a population of cells coexpressing basal and luminal cell-type cytokeratins in primary and hormone-independent prostatic carcinoma. Since amplifying cells are defined in the stem cell model as precursors of transit (luminal) cells in the hierarchical pathway of prostatic epithelium differentiation, we postulate that on the basis of the keratin expression profile this subpopulation is most likely the target for neoplastic transformation.
1 To whom requests for reprints should be addressed, at Urological Research Laboratory, University Hospital Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Received 1/27/92. Accepted 9/ 4/92.
This article has been cited by other articles:
|
|
 |
|
  R.U. Lukacs, D.A. Lawson, L. Xin, Y. Zong, I. Garraway, A.S. Goldstein, S. Memarzadeh, and O.N. Witte Epithelial Stem Cells of the Prostate and Their Role in Cancer Progression Cold Spring Harb Symp Quant Biol, November 6, 2008; (2008) sqb.2008.73.012v1. [Abstract] [PDF]
|
|
|
|
 |
|
 J. C. Symes, M. Kurin, N. E. Fleshner, and J. A. Medin Fas-mediated killing of primary prostate cancer cells is increased by mitoxantrone and docetaxel Mol. Cancer Ther., September 1, 2008; 7(9): 3018 - 3028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yan, H. Erdem, R. Li, Y. Cai, G. Ayala, M. Ittmann, L.-y. Yu-Lee, S. Y. Tsai, and M.-J. Tsai Steroid Receptor Coactivator-3/AIB1 Promotes Cell Migration and Invasiveness through Focal Adhesion Turnover and Matrix Metalloproteinase Expression Cancer Res., July 1, 2008; 68(13): 5460 - 5468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mimeault, P. P. Mehta, R. Hauke, and S. K. Batra Functions of Normal and Malignant Prostatic Stem/Progenitor Cells in Tissue Regeneration and Cancer Progression and Novel Targeting Therapies Endocr. Rev., April 1, 2008; 29(2): 234 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Mackern-Oberti, M. Maccioni, C. Cuffini, G. Gatti, and V. E. Rivero Susceptibility of Prostate Epithelial Cells to Chlamydia muridarum Infection and Their Role in Innate Immunity by Recruitment of Intracellular Toll-Like Receptors 4 and 2 and MyD88 to the Inclusion Infect. Immun., December 1, 2006; 74(12): 6973 - 6981. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Gatti, V. Rivero, R. D. Motrich, and M. Maccioni Prostate epithelial cells can act as early sensors of infection by up-regulating TLR4 expression and proinflammatory mediators upon LPS stimulation J. Leukoc. Biol., May 1, 2006; 79(5): 989 - 998. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.P. Burden, C.H. Holmes, R. Persad, and K. Whittington Prostasomes--their effects on human male reproduction and fertility Hum. Reprod. Update, May 1, 2006; 12(3): 283 - 292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Kogan, N. Goldfinger, M. Milyavsky, M. Cohen, I. Shats, G. Dobler, H. Klocker, B. Wasylyk, M. Voller, T. Aalders, et al. hTERT-Immortalized Prostate Epithelial and Stromal-Derived Cells: an Authentic In vitro Model for Differentiation and Carcinogenesis. Cancer Res., April 1, 2006; 66(7): 3531 - 3540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Xin, D. A. Lawson, and O. N. Witte The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis PNAS, May 10, 2005; 102(19): 6942 - 6947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.A. LAWSON, L. XIN, R. LUKACS, Q. XU, D. CHENG, and O.N. WITTE Prostate Stem Cells and Prostate Cancer Cold Spring Harb Symp Quant Biol, January 1, 2005; 70(0): 187 - 196. [Abstract] [PDF]
|
|
|
|
|
|
O. Imamov, A. Morani, G.-J. Shim, Y. Omoto, C. Thulin-Andersson, M. Warner, and J.-A. Gustafsson Estrogen receptor {beta} regulates epithelial cellular differentiation in the mouse ventral prostate PNAS, June 22, 2004; 101(25): 9375 - 9380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Schwarze, V. X. Fu, and D. F. Jarrard Cdc37 Enhances Proliferation and Is Necessary for Normal Human Prostate Epithelial Cell Survival Cancer Res., August 1, 2003; 63(15): 4614 - 4619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. V. Litvinov, A. M. De Marzo, and J. T. Isaacs Is the Achilles' Heel for Prostate Cancer Therapy a Gain of Function in Androgen Receptor Signaling? J. Clin. Endocrinol. Metab., July 1, 2003; 88(7): 2972 - 2982. [Full Text] [PDF]
|
|
|
|
 |
|
 G. J. L. H. van Leenders, W. R. Gage, J. L. Hicks, B. van Balken, T. W. Aalders, J. A. Schalken, and A. M. De Marzo Intermediate Cells in Human Prostate Epithelium Are Enriched in Proliferative Inflammatory Atrophy Am. J. Pathol., May 1, 2003; 162(5): 1529 - 1537. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. P. Tran, C. Lin, J. Yamashiro, and R. E. Reiter Prostate Stem Cell Antigen Is a Marker of Late Intermediate Prostate Epithelial Cells Mol. Cancer Res., December 1, 2002; 1(2): 113 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Meeker, J. L. Hicks, E. A. Platz, G. E. March, C. J. Bennett, M. J. Delannoy, and A. M. De Marzo Telomere Shortening Is an Early Somatic DNA Alteration in Human Prostate Tumorigenesis Cancer Res., November 15, 2002; 62(22): 6405 - 6409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chen, J. Wang, M. M. Fraig, J. Metcalf, W. R. Turner, N. K. Bissada, D. K. Watson, and C. W. Schweinfest Defects of DNA Mismatch Repair in Human Prostate Cancer Cancer Res., May 1, 2001; 61(10): 4112 - 4121. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. L. Hudson, A. T. Guy, P. Fry, M. J. O'Hare, F. M. Watt, and J. R.W. Masters Epithelial Cell Differentiation Pathways in the Human Prostate: Identification of Intermediate Phenotypes by Keratin Expression J. Histochem. Cytochem., February 1, 2001; 49(2): 271 - 278. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. Abate-Shen and M. M. Shen Molecular genetics of prostate cancer Genes & Dev., October 1, 2000; 14(19): 2410 - 2434. [Full Text]
|
|
|
|
|
|
A. M. De Marzo, V. L. Marchi, J. I. Epstein, and W. G. Nelson Proliferative Inflammatory Atrophy of the Prostate : Implications for Prostatic Carcinogenesis Am. J. Pathol., December 1, 1999; 155(6): 1985 - 1992. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Lin, C. Ferguson, J. T. White, S. Wang, R. Vessella, L. D. True, L. Hood, and P. S. Nelson Prostate-localized and Androgen-regulated Expression of the Membrane-bound Serine Protease TMPRSS2 Cancer Res., September 1, 1999; 59(17): 4180 - 4184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F. Jarrard, S. Sarkar, Y. Shi, T. R. Yeager, G. Magrane, H. Kinoshita, N. Nassif, L. Meisner, M. A. Newton, F. M. Waldman, et al. p16/pRb Pathway Alterations Are Required for Bypassing Senescence in Human Prostate Epithelial Cells Cancer Res., June 1, 1999; 59(12): 2957 - 2964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D Danielpour Transdifferentiation of NRP-152 rat prostatic basal epithelial cells toward a luminal phenotype: regulation by glucocorticoid, insulin-like growth factor-I and transforming growth factor-beta J. Cell Sci., January 1, 1999; 112(2): 169 - 179. [Abstract] [PDF]
|
|
|
|
|
|
A. M. De Marzo, A. K. Meeker, J. I. Epstein, and D. S. Coffey Prostate Stem Cell Compartments : Expression of the Cell Cycle Inhibitor p27Kip1 inNormal, Hyperplastic, and Neoplastic Cells Am. J. Pathol., September 1, 1998; 153(3): 911 - 919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Reiter, Z. Gu, T. Watabe, G. Thomas, K. Szigeti, E. Davis, M. Wahl, S. Nisitani, J. Yamashiro, M. M. Le Beau, et al. Prostate stem cell antigen: A cell surface marker overexpressed in prostate cancer PNAS, February 17, 1998; 95(4): 1735 - 1740. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
