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Clonal Rearrangement of Chromosome Band 6p21 in the Mesenchymal Component of Pulmonary Chondroid Hamartoma¹

Department of Pathology [J. A. F., G. S. P., K. D., R. N., J. L. P., J. L.] and Division of Thoracic Surgery [D. J. S., S. M.], Brigham and Women's Hospital; the Division of Pediatric-Oncology, Dana-Farber Cancer Institute [J. A. F.]; the Division of Hematology-Oncology, Children's Hospital [J. A. F.]; and the Departments of Pathology, Surgery, and Pediatrics, Harvard Medical School, Boston, Massachusetts 02115

Pulmonary chondroid hamartomas (PCH) are biphasic benign tumors that contain both mesenchymal and epithelial populations. In this report we describe two PCH in which clonal translocations at chromosome band 6p21 were demonstrated in mesenchymal cells. One of these had a unique translocation, t(6;14)(p21;q24), that was also found in one of two PCH karyotyped previously. The t(6;14) has not been described in other varieties of benign or malignant neoplasia. The 6p21 aberrations are of particular interest because break points in this chromosomal region appear to be characteristic of endometrial polyps. Endometrial polyps, like PCH, are biphasic benign tumors in which mesenchymal clonality has been demonstrated.

¹ This study was supported in part by a Physician-Scientist Award (1K11CA01498-02) to J. A. F. from the NIH.

² To whom requests for reprints should be addressed, at Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115.

Received 4/29/92. Accepted 9/10/92.

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