| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032 [T. K. H., C. Q. P., Z. Y. H.]; and Department of Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523 [D. V., C. A. W.]
Although chrysotile asbestos is a proven human carcinogen, several studies have concluded that these fibers are not mutagenic to cultured mammalian cells. We show here, on the other hand, that when tested using the AL cell system that detects both intragenic and multilocus mutations, chrysotile is indeed mutagenic and comparable in strength to that of 
-rays. Southern analysis of the induced mutants shows that the majority contains large deletions ranging in size from a few thousand to several million base pairs. Results of our study demonstrate that, while chrysotile may be less durable in vivo than the amphibole fibers such as crocidolites and amosites, it can effectively create genetic damage involved in the cancer process.
1 Supported by National Institute of Environmental Health Sciences Grant ES 05801 and National Cancer Institute Grants CA49062, CA36447, and CA09236.
2 To whom requests for reprints should be addressed, at the Center for Radiological Research, College of Physicians and Surgeons, Columbia University, VC11-218, 630 West 168th St., New York, NY 10032.
3 C. A. W. is a member of the Cancer Center at the University of Colorado School of Medicine.
Received 6/ 1/92. Accepted 9/11/92.
This article has been cited by other articles:
|
|
 |
|
  M Filipic, T Fatur, and M Vudrag Molecular mechanisms of cadmium induced mutagenicity Human and Experimental Toxicology, February 1, 2006; 25(2): 67 - 77. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Persaud, H. Zhou, S. E. Baker, T. K. Hei, and E. J. Hall Assessment of Low Linear Energy Transfer Radiation-Induced Bystander Mutagenesis in a Three-Dimensional Culture Model Cancer Res., November 1, 2005; 65(21): 9876 - 9882. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sabo-Attwood, M. Ramos-Nino, J. Bond, K. J. Butnor, N. Heintz, A. D. Gruber, C. Steele, D. J. Taatjes, P. Vacek, and B. T. Mossman Gene Expression Profiles Reveal Increased mClca3 (Gob5) Expression and Mucin Production in a Murine Model of Asbestos-Induced Fibrogenesis Am. J. Pathol., November 1, 2005; 167(5): 1243 - 1256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-X. Liu, M. M. Davidson, X. Tang, W. F. Walker, M. Athar, V. Ivanov, and T. K. Hei Mitochondrial Damage Mediates Genotoxicity of Arsenic in Mammalian Cells Cancer Res., April 15, 2005; 65(8): 3236 - 3242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Ramos-Nino, L. Scapoli, M. Martinelli, S. Land, and B. T. Mossman Microarray Analysis and RNA Silencing Link fra-1 to cd44 and c-met Expression in Mesothelioma Cancer Res., July 1, 2003; 63(13): 3539 - 3545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. SUZUKI and S. R. YUEN Asbestos Fibers Contributing to the Induction of Human Malignant Mesothelioma Ann. N.Y. Acad. Sci., December 1, 2002; 982(1): 160 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Unfried, C. Schurkes, and J. Abel Distinct Spectrum of Mutations Induced by Crocidolite Asbestos: Clue for 8-Hydroxydeoxyguanosine-dependent Mutagenesis in Vivo Cancer Res., January 1, 2002; 62(1): 99 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhou, M. Suzuki, G. Randers-Pehrson, D. Vannais, G. Chen, J. E. Trosko, C. A. Waldren, and T. K. Hei Radiation risk to low fluences of alpha particles may be greater than we thought PNAS, December 4, 2001; 98(25): 14410 - 14415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. L. Zhao, C. Q. Piao, L. J. Wu, M. Suzuki, and T. K. Hei Differentially expressed genes in asbestos-induced tumorigenic human bronchial epithelial cells: implication for mechanism Carcinogenesis, November 1, 2000; 21(11): 2005 - 2010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Ansari and T. K. Hei Effects of 60 Hz extremely low frequency magnetic fields (EMF) on radiation- and chemical-induced mutagenesis in mammalian cells Carcinogenesis, June 1, 2000; 21(6): 1221 - 1226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Gustafson, H. R. Franz, A. M. Ueno, C. J. Smith, D. J. Doolittle, and C. A. Waldren Vanillin (3-methoxy-4-hydroxybenzaldehyde) inhibits mutation induced by hydrogen peroxide, N-methyl-N-nitrosoguanidine and mitomycin C but not 137Cs {gamma}-radiation at the CD59 locus in human-hamster hybrid AL cells Mutagenesis, May 1, 2000; 15(3): 207 - 213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Xu, L.-J. Wu, R. M. Santella, and T. K. Hei Role of Oxyradicals in Mutagenicity and DNA Damage Induced by Crocidolite Asbestos in Mammalian Cells Cancer Res., December 1, 1999; 59(23): 5922 - 5926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. W Kamp and S. A Weitzman The molecular basis of asbestos induced lung injury Thorax, July 1, 1999; 54(7): 638 - 652. [Full Text]
|
|
|
|
|
|
L.-J. Wu, G. Randers-Pehrson, A. Xu, C. A. Waldren, C. R. Geard, Z. Yu, and T. K. Hei Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells PNAS, April 27, 1999; 96(9): 4959 - 4964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. K. Hei, S. X. Liu, and C. Waldren Mutagenicity of arsenic in mammalian cells: Role of reactive oxygen species PNAS, July 7, 1998; 95(14): 8103 - 8107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. K. Hei, L.-J. Wu, S.-X. Liu, D. Vannais, C. A. Waldren, and G. Randers-Pehrson Mutagenic effects of a single and an exact number of alpha particles in mammalian cells PNAS, April 15, 1997; 94(8): 3765 - 3770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhou, G. Randers-Pehrson, C. A. Waldren, D. Vannais, E. J. Hall, and T. K. Hei Induction of a bystander mutagenic effect of alpha particles in mammalian cells PNAS, February 29, 2000; 97(5): 2099 - 2104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. X. Liu, M. Athar, I. Lippai, C. Waldren, and T. K. Hei Induction of oxyradicals by arsenic: Implication for mechanism of genotoxicity PNAS, February 13, 2001; 98(4): 1643 - 1648. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Cell Growth & Differentiation |
