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Inhibitory Effect of Green Tea on the Growth of Established Skin Papillomas in Mice¹

Laboratory for Cancer Research, Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway 08855, New Jersey [Z. Y. W., M-T. H., R. C., W. M., T. F., C. S. Y., A. H. C.]; Department of Food Science, Cook College, Rutgers, The State University of New Jersey, New Brunswick 08901 [C-T. H.]; and Neurotoxicology Laboratories, Department of Pharmacology and Toxicology, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway 08855 [K. R. R.], New Jersey

² To whom requests for reprints should be addressed.

In 10 separate experiments, mice with established chemically induced or UV light-induced skin papillomas were treated continuously with green tea in the drinking water or with i.p. injections of a green tea polyphenol fraction or (–)-epigallocatechin gallate three times a week for 4–10 weeks. Partial tumor regression or >90% inhibition of tumor growth, as measured by changes in tumor volume per mouse, was observed in 5 experiments, and marked inhibition of tumor growth (46–89%) was observed in 5 additional experiments. Treatment of the mice with green tea or green tea constituents had an inhibitory effect on body weight increases in several but not all of the studies. Examination of the data from all ten experiments revealed that complete tumor regression occurred in 14 of 346 papilloma-bearing mice (4%) that were treated with green tea in the drinking water or with i.p. injections of green tea constituents, whereas none of the 220 papilloma-bearing control mice treated with only vehicle exhibited complete tumor regression. These observations indicate that oral administration of green tea, i.p. administration of a green tea polyphenol fraction, or i.p. administration of (–)-epigallocatechin gallate inhibited the growth and/or caused the regression of established experimentally induced skin papillomas.

¹ Supported in part by Grants CA49756 and ES05022 from the NIH.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Received 6/30/92. Accepted 9/24/92.

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