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Preuss Laboratory for Molecular Neuro-Oncology, Brain Tumor Research Center, Department of Neurological Surgery [S. A. R., M. A. I.],, and Department of Pathology [R. D.] and Neurological Surgery [M. R.], School of Medicine, University of California, San Francisco, California 94143 and Molecular Genetics Section, Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892 [S. ,A. R., C. C. K., M. A. I.]
1 To whom requests for reprints should be addressed.
In experiments to identify molecules that might be important in the pathogenesis of glioblastoma multiforme, the most common malignant brain tumor, we found that annexin II (Lipocortin 2, p36), a likely second messenger in several different mitogenic pathways, was highly expressed in tumor tissue of glioblastoma multiforme (9 of 9) and highly anaplastic astrocytoma (2 of 6), but not in astrocytomas of lower pathological grade (0 of 6). We also detected high levels of annexin II expression in fetal brain during the period when radial glia proliferate, although annexin II expression was not detected in normal adult brain. These data demonstrate that annexin II expression is developmentally regulated in the human central nervous system and suggest that the early progenitor radial glia share important characteristics with highly malignant glial tumors.
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Received 6/18/92. Accepted 10/ 6/92.
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