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FLT4, a Novel Class III Receptor Tyrosine Kinase in Chromosome 5q33-qter¹

Cancer Biology Laboratory, Departments of Virology and Pathology, and Transplantation Laboratory, University of Helsinki, Haartmaninkatu 3, 00290 Helsinki 29, Finland [O. A., K. P., J. P., E. A., R. A., K. A.]; Department of Biological Chemistry, University of California, Irvine, California 92717 [S. K. B., J. M., J. W.]; and Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5541 [K. H.]

The receptors for at least two hematopoietic growth factors, namely the stem cell factor and colony-stimulating factor 1, belong to class III receptor tyrosine kinases. Here we describe cloning of a partial complementary DNA for FLT4, an additional member of this gene family from human leukemia cells. The FLT4 tyrosine kinase domain is 79% homologous with the previously cloned FLT1 (M. Shibuya et al., Oncogene, 5: 519–524, 1990) tyrosine kinase and maps to the chromosomal region 5q33-qter. We have found FLT4 expression in human placenta, lung, heart, and kidney, whereas the pancreas and brain appeared to contain very little if any FLT4 RNA. The results suggest that FLT4 functions in multiple adult tissues.

¹ This study was supported by the Finnish Cancer Organizations, The Finnish Academy, The Sigrid Juselius and Finnish Cultural Foundations, Orion Corporation Research Fund, and the Research and Science Foundation of Farms, and by NIH Grant CA 21124.

Received 10/22/91. Accepted 12/ 4/91.

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