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A Gene from Human Chromosome Region 3p21 with Reduced Expression in Small Cell Lung Cancer¹

MRC Human Biochemical Genetics Unit, University College London, 4 Stephenson Way, London NW1 2H3, United Kingdom [B. C., A. P., K. G.]; Department of Medical Genetics, University of Groningen, Ant. Deusinglaan 4, 9713 AW Groningen, The Netherlands [K. K., A. v. d. B., J. O., R. M. W. H., A. Y. v. d. V., C. H. C. M. B.]; Department of Clinical Neurology, Institute of Neurology, Queens Square, London WC1N 3BG, United Kingdom [M. B. D.]; and MRC Clinical Oncology & Radiotherapeutics Unit, MRC Centre, Hills Road, Cambridge, United Kingdom [P. H. R.]

A combination of cytogenetic and molecular studies has implicated the p21 region of human chromosome 3 as the probable site of a gene the loss of which contributes to the development of small cell lung cancer. We report here the isolation of a gene from this region which is expressed in normal lung tissue and in cell lines derived from a number of different types of tumor, but the expression of which in small cell lung cancer cell lines is undetectable by RNA blot analysis. Although the more sensitive polymerase chain reaction did detect transcripts, a novel quantitative polymerase chain reaction assay showed that their concentration in small cell lung cancer cell lines is less than 3% of that in normal lung.

¹ This work was supported in part by the Dutch Cancer Society.

Received 9/ 6/91. Accepted 1/ 7/92.

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