| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030 [K. A. S., J. S. B., B. L. S.]; and Shanghai Institute of Biochemistry, Academia Sinica, Shanghai 200031, China [Y-Z. Z.]
DNA samples from 36 hepatocellular carcinoma (HCC) patients from China were screened for a specific mutation affecting codon 249 of the p53 gene, recently identified as a hotspot mutation in some HCCs. We detected the tumor-specific p53 codon 249 mutation in 21 (58%) of 36 HCCs examined. Thirteen patients with the specific codon 249 mutation had lost the remaining allele of p53, whereas the remaining eight patients appeared to have retained both copies of the gene. These results suggest that alterations of p53 may be important events in the genesis of HCCs and that point mutation may precede allele loss.
1 Supported by Grant CA54557 (B. L. S.) from the National Cancer Institute.
2 To whom requests for reprints should be addressed, at the Division of Molecular Virology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030.
Received 12/12/91. Accepted 1/31/92.
This article has been cited by other articles:
|
|
 |
|
  K. Szymanska, J.-G. Chen, Y. Cui, Y. Y. Gong, P. C. Turner, S. Villar, C. P. Wild, D. M. Parkin, and P. Hainaut TP53 R249S Mutations, Exposure to Aflatoxin, and Occurrence of Hepatocellular Carcinoma in a Cohort of Chronic Hepatitis B Virus Carriers from Qidong, China Cancer Epidemiol. Biomarkers Prev., May 1, 2009; 18(5): 1638 - 1643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Jackson, I. Lea, A. Rashid, S. D. Peddada, and J. K. Dunnick Genetic Alterations in Cancer Knowledge System: Analysis of Gene Mutations in Mouse and Human Liver and Lung Tumors Toxicol. Sci., April 1, 2006; 90(2): 400 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-L. Hsieh, H.-T. Chien, I-H. Chen, C.-T. Liao, H.-M. Wang, S.-M. Jung, P.-F. Wang, J. T.-C. Chang, M.-C. Chen, and A.-J. Cheng The XRCC1 399Gln Polymorphism and the Frequency of p53 Mutations in Taiwanese Oral Squamous Cell Carcinomas Cancer Epidemiol. Biomarkers Prev., May 1, 2003; 12(5): 439 - 443. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-P. Ching, C.-M. Wong, S.-F. Chan, T. H.-Y. Leung, D. C.-H. Ng, D.-Y. Jin, and I. O.-l. Ng Deleted in Liver Cancer (DLC) 2 Encodes a RhoGAP Protein with Growth Suppressor Function and Is Underexpressed in Hepatocellular Carcinoma J. Biol. Chem., March 14, 2003; 278(12): 10824 - 10830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.P. Wild and P.C. Turner The toxicology of aflatoxins as a basis for public health decisions Mutagenesis, November 1, 2002; 17(6): 471 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-L. Hsieh, P.-F. Wang, I.-H. Chen, C.-T. Liao, H.-M. Wang, M.-C. Chen, J. T.-C. Chang, and A.-J. Cheng Characteristics of mutations in the p53 gene in oral squamous cell carcinoma associated with betel quid chewing and cigarette smoking in Taiwanese Carcinogenesis, September 1, 2001; 22(9): 1497 - 1503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Stern, D. M. Umbach, M. C. Yu, S. J. London, Z.-Q. Zhang, and J. A. Taylor Hepatitis B, Aflatoxin B1, and p53 Codon 249 Mutation in Hepatocellular Carcinomas from Guangxi, People's Republic of China, and a Meta-analysis of Existing Studies Cancer Epidemiol. Biomarkers Prev., June 1, 2001; 10(6): 617 - 625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-S. Jeng, I-S. Sheen, B.-F. Chen, and J.-Y. Wu Is the p53 Gene Mutation of Prognostic Value in Hepatocellular Carcinoma After Resection? Arch Surg, November 1, 2000; 135(11): 1329 - 1333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Preisler, W. J. Caspary, F. Hoppe, R. Hagen, and H. Stopper Aflatoxin B1-induced mitotic recombination in L5178Y mouse lymphoma cells Mutagenesis, January 1, 2000; 15(1): 91 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Tam, J. F. Foley, T. R. Devereux, R. R. Maronpot, and T. E. Massey High Frequency and Heterogeneous Distribution of p53 Mutations in Aflatoxin B1-induced Mouse Lung Tumors Cancer Res., August 1, 1999; 59(15): 3634 - 3640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F Aguilar, C. Harris, T Sun, M Hollstein, and P Cerutti Geographic variation of p53 mutational profile in nonmalignant human liver Science, May 27, 1994; 264(5163): 1317 - 1319. [Abstract] [PDF]
|
|
|
|
 |
|
 Platform Presentations Toxicol Pathol, November 1, 1993; 21(6): 611 - 623. [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
