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Allelotype of Non-Small Cell Lung Carcinoma—Comparison between Loss of Heterozygosity in Squamous Cell Carcinoma and Adenocarcinoma¹

Departments of Pathology [E. T., S-Y. W., H. S., T. K.], Biochemistry [Y. N.], and Surgery [K. N., S. T.], Cancer Institute, Tokyo, 1-37-1, Kami-Ikebukuro, Toshimaku, Tokyo 170, Japan

We examined loss of heterozygosity (LOH) on all autosomal chromosomes in 53 non-small cell lung carcinomas. Frequent LOH was observed on the long arms of chromosomes 1 (37%), 2 (31%), 5 (30%), 8 (31%), and 13 (32%), and the short arms of chromosomes 3 (54%) and 17 (62%). LOH on chromosomes 3p and 17p was observed in all informative cases of squamous cell carcinoma, but was significantly less frequent in adenocarcinomas (P = 0.003 and 0.001, respectively). Similarly, LOH on chromosome 13q was observed frequently in squamous cell carcinomas (5 of 9 informative cases, or 56%), but in only 5 of 26, or 19%, of adenocarcinomas. In contrast, LOH on chromosome 2q was observed only in adenocarcinomas. In addition, this chromosomal arm was lost more frequently in poorly differentiated, compared to well differentiated adenocarcinomas. Furthermore, a correlation between fractional allelic loss and pathohistological grade was identified. These results implicate the presence of several tumor suppressor genes associated with development and/or progression of non-small cell lung carcinomas.

¹ This work was supported by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture, and by the Smoking Research Foundation.

² To whom requests for reprints should be addressed, at Department of Pathology, Cancer Institute, Tokyo, 1-37-1, Kami-Ikebukuro, Toshima-ku, Tokyo 170, Japan.

Received 12/10/91. Accepted 2/25/92.

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