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[Cancer Research 53, 3569-3573, August 1, 1993]
© 1993 American Association for Cancer Research
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Evidence for in Situ Amplification of Cytotoxic T-Lymphocytes with Antitumor Activity in a Human Regressive Melanoma

Andreas Mackensen1, Laurent Ferradini, Guislaine Carcelain, Frederic Triebel, Florence Faure, Sophie Viel and Thierry Hercend

Laboratoire d'Hemato-Immunologie, INSERM U333, Institut Gustave Roussy, 39 rue Camille Desmoulins, F-94805 Villejuif Cedex, France

We have derived from lymphocytes infiltrating a human regressive melanoma lesion a series of T-cell receptor {alpha}/ß-dependent, HLA-B14-restricted cytotoxic T-lymphocyte clones reactive against the autologous tumor. Analysis of the T-cell receptor gene expression revealed that all the clones represented a unique cell expressing a Vß13.1/Jß1.1 gene segment. T-cell receptor transcripts expressed in the cloned cells were compared to those present in the uncultured tumor tissue. This analysis demonstrated that the specific cytotoxic T-lymphocyte clones characterized in vitro was actually selected and amplified in vivo at the lesion site. These results provide strong evidence that effector T-cells have contributed to tumor regression.

1 Recipient of a fellowship from the Deutsche Forschungsgemeinschaft (Ma 1351/1-1). To whom requests for reprints should be addressed.

Received 5/ 3/93. Accepted 6/16/93.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1993 by the American Association for Cancer Research.