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Laboratory of Oral Medicine, National Institute of Dental Research [M. S. L., J. L., A. L. N.], NIH, Bethesda 20892, and National Cancer Institute-Navy Oncology Branch, National Naval Medical Center [E. K. R., B. E. J.], Bethesda, Maryland 20889-5105
IA-1 is a recently isolated novel complementary DNA which encodes a protein of 510 amino acids that contains both a zinc finger DNA-binding domain and a putative prohormone domain. mRNA expression of IA-1 has been found thus far only in tumors of neuroendocrine origin. In this report we describe the expression of IA-1 mRNA in a panel of 64 human lung cancer cell lines. IA-1 mRNA was detected by Northern blot analysis in 97% (30 of 31) of small cell lung cancer cell lines. In contrast, IA-1 mRNA was detected in only 13% (4 of 30) of non-small cell lung cancer cell lines. Nine of the 30 (30%) expressed either chromogranin A mRNA or produced L-dopa decarboxylase. Four of these 9 (44%) had detectable levels of IA-1 mRNA. In most of the lung cancer cell lines examined, IA-1 showed high concordance with the other neuroendocrine markers, L-dopa decarboxylase, and chromogranin A. The one exception was a variant small cell lung cancer cell line which expressed low or nondetectable levels of L-dopa decarboxylase. IA-1 is a candidate marker of neuroendocrine differentiation of human lung tumors.
1 To whom requests for reprints should be addressed, at Laboratory of Oral Medicine, National Institute of Dental Research, NIH, Building 30, Room 121, Bethesda, MD 20892.
Received 7/ 7/93. Accepted 8/ 3/93.
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